急性髓细胞白血病治疗前后端粒酶活性定量检测临床分析  

Clinical analysis on quantitative detection of activity of tlomerase before and after treatment in 14 cases of acute myeloid leukmia

作　　者：白晶[1] 于海燕 卞隽 

机构地区：[1]中国人民解放军第208医院,130062 [2]吉林省肿瘤医院,130012

出　　处：《吉林医学》2000年第5期263-264,共2页Jilin Medical Journal

摘　　要：目的 :探讨端粒酶活性髓细胞性白血病 (AML )的诊断、治疗及预后的临床意义。方法 :采用 TRAP- EL ISA定量检测 AML 端粒酶活性。结果 :14例 AML端粒酶活性 OD(0 .2 38± 0 .0 42 )明显高于正常组 (0 .0 94± 0 .0 0 3) ;而化疗前明显高于缓解病例。结论 :该检测方法是诊断 AML 良好手段。了解化疗前后 AML病人的端粒酶活性对于判断疾病恶性程度、预后和指导治疗。Objective Study the clinical significance which the activity of telomerase diagnoses,treats and prognoses the acute myeloid leukmia.Method Take TRAP ELISA to detect the activity of telomerase quantitatively.Results 14 cases AML activity of telomerase OD(0 238±0 042),are obviously higher than the normal cases,but higher than recuperate cases before medical treatment.Conclusion The method of detection is a good way to diagnose AML.It has an important clinical significance to know that the activity of telomerase of AML patients,prognoses and directs treatment,indicates the earlier relapse before and after medical treatment.

关 键 词：白血病 髓样 急性 端粒酶 骨髓 

分 类 号：R733.710.5[医药卫生—肿瘤]