介入治疗实验研究中兔VX2肝癌模型制作的改进和CT评价  

Improvement in Making Rabbit Model Bearing VX2 Liver Tumor for Interventional Experimental Study and CT Evaluation of the Tumor

作　　者：邵国良[1] 周康荣[1] 王建华[1] 颜志平[1] 刘嵘[1] 

机构地区：[1]复旦大学医学院附属中山医院放射科,200032

出　　处：《临床放射学杂志》2000年第10期653-654,共2页Journal of Clinical Radiology

基　　金："九五"国家医学科技攻关项目!(96- 907-03-01)

摘　　要：目的　改进兔VX2肝癌模型的制作使之更适合介入治疗学研究 ,同时探讨瘤灶的CT表现及螺旋CT在检测瘤灶中的作用。材料与方法　实验动物为新西兰大白兔 (80只 ) ,瘤种采用动物自身接种传代保存。取瘤块组织 (1～ 2mm3 大小 )接种肝脏左叶深部 ,于接种后 7、14天分别行CT平扫、动脉早期、门脉期扫描 ,少数动物于接种后 2 1天再次CT扫描。结果　 72只 (90 % )动物接种成功。瘤灶以种植后 2周CT显示最清楚和典型 ,直径 1～ 2cm左右 ,平扫呈低密度或等密度 ,动脉早期明显强化 ,门脉期呈低密度 ,与周围肝组织分界较清楚。肝动脉造影显示肿瘤富血供。而种植后超过Objective To improve the preparation of rabbit model bearing VX2 liver tumor for interventional experimental study, and to investigate CT features of the tumor.Materials and Methods Eighty New Zealand white rabbits were implanted with VX2 tumor in the deep aspect of the left lobe of liver. CT scanning was performed in the experimental animals 1 and 2 weeks after implantation. The plain, early arterial phase and portal phase images were obtained. Additional CT scan at 3 weeks after implantation was made in some animals.Results Seventy two (90%) rabbits were successfully implanted with VX2 tumor in the liver. On CT scans took at 2 weeks after implantation the tumor demonstrated itself most clear and typical: 1～2cm in diameter, hypodensity or isodensity on plain CT scans, marked enhanced on early arterial phase images, hypodensity on portal phase images, well discernible from the surrounding liver tissue. Hepatic angiography showed that the tumor was hypervascular. Necrosis was seen in most animals at 3 weeks after implantation.Conclusion The rabbit model bearing VX2 liver tumor is more suitable for interventional experimental study. Spiral CT is very useful in evaluating tumor.

关 键 词：VX2肿瘤 肝癌 介入放射学 实验研究 CT 

分 类 号：R735.7[医药卫生—肿瘤]