b-FGF在肾癌组织中表达的临床意义  

Expression of b FGF in renal cell carcinoma

作　　者：车乐[1] 朱积川[2] 姜辉[2] 李鹰[2] 王晓峰[2] 侯树坤[2] 

机构地区：[1]北京军区总医院泌尿外科 [2]北京大学人民医院泌尿外科,100044

出　　处：《中华泌尿外科杂志》2000年第10期596-598,共3页Chinese Journal of Urology

摘　　要：目的　探讨b FGF(碱性成纤维细胞生长因子 )在肾癌中表达的临床意义。　方法　采用斑点杂交技术和免疫组化技术测定 2 0例肾癌患者癌组织、癌旁和正常肾组织b FGF表达情况。　结果　肾癌组织中b FGF表达明显高于癌旁和周围正常肾组织 (P <0 .0 1)。b FGF表达升高与肿瘤分期、分级密切相关 ,与肿瘤大小无明显关系。　结论　b FGF为肾癌组织自身分泌 。Objective To investigate the clinical significance of b FGF in human renal carcinoma. Methods 20 cases of renal carcinoma were examined using RNA dot blot hybridization and immunohistochemical technique. Results b FGF expression was significantly higher in human renal cancer tissue than the normal human renal tissue and tissue surrounding the tumor. b FGF expression was of no statistic significance as to tumor size, but it was of statistic significance as to clinical stage or clinical grade. Conclusions b FGF is secreted from tumor tissue itself. b FGF is closely involved in the development and growth of renal cell carcinoma.

关 键 词：肾癌 碱性成纤维细胞生长因子 免疫组织化学 

分 类 号：R737.11[医药卫生—肿瘤]