人乳头状瘤病毒感染与宫颈癌预后的关系  

Relationship Between the Infection of HPV and the Prognosis of Cervical Cancer

作　　者：陈亦乐[1] 王静[1] 陈森林[1] 刘保安[1] 吴晓英[2] 张淑安[2] 彭隆祥[2] 

机构地区：[1]湖南省肿瘤医院,中国湖南长沙410006 [2]湖南医科大学电镜中心,中国湖南长沙410078

出　　处：《湖南医学》2000年第5期332-334,共3页Hunan Medical Journal

基　　金：湖南省卫生厅资助

摘　　要：目的探讨人乳头状瘤病毒 (HPV )感染与宫颈癌预后的关系 ,揭示HPV的可能致癌作用。方法用原位杂交的方法测定每例癌组织中HPV的表达 ,用统计方法比较不同生存率组HPV阳性率的差异 ,分析HPV感染对预后的影响。结果在 94例经手术、化疗等治疗宫颈癌患者中 ,存活 10年以下患者组 (4 4例 )的HPV阳性率远远高于 10年以上 (5 0例 )的患者组 (P <0 .0 1)。比较临床分期为Ⅱb患者 ,存活 10年以内 33例患者HPV阳性率明显高于存活 10年以上的 35例 (P <0 .0 1)。结论HPV感染与宫颈癌预后密切相关 ,HPV阳性者预后差。Objective To study the relation between the infection of human papilloma virus (HPV) and the prognosis of cervical cancer ,exploring the possible carcinogenesis of HPV. Methods The expressions of HPV16/18 DNA in cervical cancers were estimated by in situ hybridization, then the relation between the positive rate of HPV16/18 DNA and the prognosis of cervical cancer was compared in different survival groups. ResultsNinty-four patients with cervical cancer were treated by operation and chemotherapy. The positive rate of HPV16/18 DNA in patients whose survival time were below 10 years (44 cases) was significantly higher than those whose survival time were over 10 years (50 cases)(P<0.01). Among the patients classified as clinical stage Ⅱ b , the positive rate of HPV16/18 DNA in those with survival time below 10 years (33 cases) was significantly higher than those whose survival time were over 10 years (35 cases)(P<0.01).Conclusions The infection of HPV is closely correlated with prognosis of cervical cancer. The patients showing positive rate of HPV 16/18 DNA tend to have poor prognosis. [

关 键 词：人乳头状瘤病毒 宫颈癌 肿瘤病毒感染 预后 

分 类 号：R737.330.7[医药卫生—肿瘤]