抑郁症患者血清精氨酸升压素水平和病情评价指标的相关性分析  

Correlation Analysis of Serum Arginine Vasopressin Levels and Disease Evaluation Indicators in the Depressed Patients

作　　者：张岳春[1] 包敏洁 凌卫明[1] 

机构地区：[1]南京医科大学附属无锡市精神卫生中心,江苏无锡214151 [2]无锡市东亭医院,江苏无锡214100

出　　处：《现代检验医学杂志》2013年第1期42-44,共3页Journal of Modern Laboratory Medicine

摘　　要：目的 探讨抑郁症患者治疗前后血清精氨酸升压素（arginine vasopressin,AVP）水平及其与病情评价指标的相关性.方法 采用酶联免疫吸附法测定2011年10月~2012年7月期间43例正常对照者、45例抑郁症患者治疗前后血清中AVP水平.采用汉密尔顿抑郁量表（hamilton rating scale for depression,HAMD）评定患者病情严重程度、韦氏记忆量表中的记忆商数（memory quotient of wechsler memory scale,WMS-MQ）评定记忆功能.患者组与对照组血清AVP水平比较以及患者组治疗前后血清AVP水平、HAMD评分、WMS-MQ评分比较用t检验.抑郁症患者AVP水平和HAMD,WMS-MQ评分的相关性用Pearson相关分析.结果 ①患者组治疗前、治疗4周后血清AVP水平分别为71.90±19.33 ng/L,90.52±24.01 ng/L,均明显低于正常对照组262.47±56.87 ng/L,差异均有统计学意义（t=20.85,P〈0.01;t=18.33,P〈0.01）;患者组治疗前后血清AVP水平变化差异有统计学意义（t=12.27,P〈0.01）.②患者组治疗4周后HAMD评分较治疗前明显下降,WMS-QC评分较治疗前明显上升,差异均有统计学意义（t=-20.12,P〈0.01;t=25.83,P〈0.01）.③患者组基线时的AVP水平与HAMD评分的相关差异无统计学意义（r=-0.26,P〉0.05）,与WMS-MQ评分呈正相关（r=0.77,P〈0.01）;AVP治疗前后变化值与HAMD减分率的相关差异也无统计学意义（r=0.05,P〉0.05）.结论 抑郁症患者存在血清AVP水平下降和记忆功能受损,AVP可能参与了抑郁症的发生,与记忆有关,但与临床疗效无关.Objective To explore the relevance about the serum AVP levels in depressed patients before and after treatment with disease evaluation indicators. Methods From October 2011 to July 2012,the serun AVP levels in 45 normal controls and 47 depressive patients before and after treatment were determined by ELISA method. The HAMD assessed patients in serious condition degree,memory quotient of WMS evaluation memory function, t test was used to compare AVP levels between depressed patients and normal control group,and compare AVP levels, HAMD scores,WMS-MQ scores of depressed patients before and after treatment. AVP levels and HAMD scores,WMS-MQ relationship used the Pearson correlation analysis. Results （1）The depressive patients before treatment, treatment after 4 weeks AVP levels were 71.90 5±9. 33 ng/L, 90.52±24. 01 ng/L, were significantly lower than normal control group 262.47±56.87 ng/L and the differences were statistically significant （t= 20.85, P〈0.01;t= 18.33, P〈0.01）. Before and after treatment, the serum AVP levels changes of depressive patients was statistically significant （t= 12.27, P〈0.01）. （2）The HAMD score of the depressive patients decreased significantly after been treated for 4 weeks （t = - 20.12, P〈0. 01）, WMS-QC score significantly increased （t= 25.83, P〈0. 01）, the difference was statistically significant. （3）At baseline, the serum AVP levels of depressive patients were no statistical significance in the correlation with HAMD score （r = - 0.26, P〉 0.05）, but were positive correlation with WMS-MQ score （r=0.77, P〈0.01）. AVP value changes before and after treatment with HAMD reduction rates were no statistical significance in the correlation （r=0.05, P〉0. 05）. Conclusion Depressive patients had decreased serum AVP levels and impairments of memory functions, AVP may be involved in the occurrence of depression, related to memory function. But with the clinical efficacy of unrelated.

关 键 词：抑郁症 精氨酸升压素 记忆功能 

分 类 号：R749.4[医药卫生—神经病学与精神病学] R446.11[医药卫生—临床医学]