直肠癌组织肿瘤转移消失蛋白的表达及其临床意义  

Expression of MIM protein in rectal carcinoma and its clinicopathological significance

作　　者：张海峰[1] 李金海[1] 戴华卫[1] 孙广正[1] 翟华伟[1] 

机构地区：[1]温州医学院附属第三医院普通外科,瑞安325200

出　　处：《浙江医学》2013年第3期163-166,共4页Zhejiang Medical Journal

摘　　要：目的探讨肿瘤转移消失（MIM）蛋白在直肠癌组织中的表达及其结合临床分期对直肠癌预后的指导意义。方法采用免疫组织化学方法检测MIM蛋白在直肠癌组织，直肠腺瘤组织，直肠正常组织中的表达，并用单因素分析其与临床病理参数的关系。用Spearman等级相关分析MIM蛋白表达水平与直肠癌患者TNM分期的关系。Kaplan-Meier生存曲线分析直肠癌患者5年生存率情况。结果直肠癌组织MIM蛋白表达阳性率（83，2％）较直肠正常组织的216％和直肠腺瘤组织的288％均明显增高（均P〈0．05）；MIM蛋白表达水平与直肠癌患者是否处于肿瘤早期、是否有3枚以上淋巴转移和肿瘤分化程度有关（均P〈0．05），与直肠癌患者的性别、年龄、肿瘤直径、CEA水平、肿瘤位置高低均无关（均P〉005）。MlM蛋白表达水平与临床TNM分期呈正相关，即临床TNM越晚期MIM蛋白表达水平越高（P〈0．05）。MlM蛋白阳性患者5年生存率明显低于阴性及弱阳性患者（P〈0．05）。结论MIM蛋白高表达可能与直肠癌的发生及生物学行为有关。并提示预后不良。Objective To investigate the expression of MIM （missing in metastasis） protein in rectal carcinoma and its clinicopathological significance. Methods The expression of MIM protein was detected by immunohistochemistry in tissue sam- ples of rectal carcinoma （n=143）, rectal adenoma （n=14） and normal rectal mucosa （n= 37）. Correlation between MIM expres- sion and clinicopathological parameters was analyzed with Spearman rank regression. Postoperative 5-year survival was evalu- ated using Kaplan-Meier survival curve. Results The expression of MIM in rectal carcinoma was higher than those in normal rectal tissue （U=179.000, P〈0.05） and rectal adenoma （U=112.500, P〈0.05）. The expression of MIM protein was correlated with clinical stage, lymphatic metastasis and tumor differentiation （separately U=256.000, 227.000, 236.500, all P〈0.05）, but not cor- related with gender, age,tumor diameter, CEA level and tumor Iocation（P 〉0.05）. MIM expression was also correlated with TNM stage of rectal cancer （r=0.369, P〈0.05）. The 5-year survival in patients with positive MIM expression was significantly poorer than those with negative or weakly positive expression （32.6% vs 67.8%, X2=6.712, P〈0.05）. Conclusion High expression of MIM protein may be associated in progression of rectal carcinoma and poor prognosis.

关 键 词：癌 直肠组织 肿瘤转移消失蛋白 临床研究 

分 类 号：R735.37[医药卫生—肿瘤]