成年血液病患者血中环磷酸腺苷和环磷酸鸟苷的含量测定分析  

Analysis of cAMP and cGMP in hematopathy patients

作　　者：许子亮[1] 孙晓明[1] 许晋[2] 吴蕴棠[3] 孙忠[3] 李睿[1] 齐玉梅[2] 秘营昌[1] 王建祥[1] 张凤奎[1] 韩忠朝[1] 

机构地区：[1]中国医学科学院中国协和医科大学血液学研究所血液病医院营养科,天津300020 [2]天津市第三中心医院营养科 [3]天津医科大学营养卫生教研室

出　　处：《临床血液学杂志》2013年第2期199-201,共3页Journal of Clinical Hematology

摘　　要：目的:了解白血病及再生障碍性贫血患者外周血中环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)的含量变化。方法:用酶标法测定外周血中cAMP和cGMP的含量。结果:与正常组相比,白血病化疗前组、白血病化疗后组以及再生障碍性贫血组(再障组)cAMP含量均显著降低,差异有统计学意义(P<0.05);白血病化疗后组cGMP含量显著增高,差异有统计学意义(P<0.05);白血病化疗前组、白血病化疗后组以及再障组cAMP与cGMP的比值均显著降低,差异有统计学意义(P<0.05)。结论:血中cAMP、cGMP含量的变化与白血病及再生障碍性贫血可能具有一定的关系。Objective：To figure out the concentration change of cAMP and cGMP in the peripheral blood of the patients of with leukemia and aplastic anemia. Method：ELISA was used to detect the concentration of cAMP and cGMP. Result：Compared with control,cAMP concentrations in all three groups including leukemia before chemotherapy group（white B group）,leukemia after chemotherapy group（white P group） and aplastic anemia group（red group）decreased dramatically,with significant statistical difference（P0.05）.The concentration of cGMP in white P group markedly increased compared with control with significant difference（P0.05）.The cAMP/cGMP in white B group,white P group and red group all markedly decreased compared with control with significant difference（P0.05）. Conclusion：The results indicated that the concentration change of cAMP,cGMP in peripheral blood could be related to pathogenesis of leukemia and aplastic anemia.

关 键 词：白血病 环磷酸腺苷 环磷酸鸟苷 再生障碍性贫血 

分 类 号：R733.7[医药卫生—肿瘤]