FDG PET/CT评估乳腺癌治疗后淋巴结转移的临床价值  

Clinical Value of 18F-FDG PET/CT in Detecting Lymph Nodal Metastases in Breast Cancer Patients Post Comprehensive Treatment

作　　者：张伟光[1] 王国慧[2] 张卫东[2] 樊卫[1] 

机构地区：[1]中山大学肿瘤防治中心//华南肿瘤学国家重点实验室核医学科,广东广州510060 [2]中山大学肿瘤防治中心//华南肿瘤学国家重点实验室医学影像与微创介入中心,广东广州510060

出　　处：《中山大学学报（医学科学版）》2013年第1期135-139,共5页Journal of Sun Yat-Sen University:Medical Sciences

摘　　要：【目的】探讨FDG PET/CT全身显像评估乳腺癌治疗后淋巴结转移的临床价值。【方法】回顾性分析我院2011年1-12月87例乳腺癌治疗后患者FDG PET/CT报告,与同期传统影像检查结果进行比较,根据病历记录、病理结果及临床随访确定两组的最终结果,计算FDG PET/CT显像与传统影像两组评估淋巴结转移的准确性、特异性、灵敏度、阳性预测值(PPV)与阴性预测值(NPV)并进行统计学分析,同时各选取10例良性淋巴结与转移淋巴结患者,计算两组淋巴结SUVmax均值并进行分析。【结果】FDG PET/CT显像评估乳腺癌治疗后淋巴结转移的准确性、敏感性、特异性、PPV与NPV分别为90.8%、94.6%、88.0%,85.4%、95.7%,传统影像分别为79.3%、73.0%、84.0%、77.1%、80.8%,两组准确性、敏感性及阴性预测值差异明显,且有统计学意义。转移淋巴结SUVmax均值为8.28±3.6,良性淋巴结SUVmax均值为4.58±1.9,两组差异较大,且有统计学意义。【结论】与传统影像技术比较,FDG PET/CT能更准确评估乳腺癌治疗后淋巴结转移。[Objective] To investigate the clinical value of t8F-FDG PET/CT in detecting the lymph nodal metastases in the patients with breast cancer post comprehensive therapy. [ Methods ] The reports of FDG PET/CT scans and conventional imaging, such as CT, MRI, and/or ultrasound, performed from January 2011 to December 2011 on 87 patients with breast cancer post treatment were retrospectively reviewed. The final results were obtained from medical records, histopathological results and follow-up at least 6 months. The accuracy, specificity, sensitivity, positive predictive value （PPV） and negative predictive value （NPV） of FDG PET/CT and conventional workup were calculated and compared. Meanwhile, We investigated the difference of SUVmax （Stand Uptake Value） of the benign and malignant lymph nodes. [Results] The accuracy, sensitivity, specificity, PPV and NPV of FDG PET/CT scan were 90.8%, 94.6%, 88.0%, 85.4%, and 95.7%. The conventional workup were 79.3%, 73.0%, 84.0%, 77.1%, and 80.8%, respectively. There were statistical difference in accuracy, sensitivity, and NPV between the two groups. The average of SUVmax of the metastatic and benign lymph nodes were 8.28 ± 3.6 and 4.58±1.9, and there was significant difference between them. [ Conclusion ] FDG PET/CT has an advantage over the conventional work-up in detecting the metastatic lymph nodes in the patients with breast cancer post comprehensive treatments.

关 键 词：乳腺癌 治疗 淋巴结转移 FDG PET CT CT MRI 

分 类 号：R737.9[医药卫生—肿瘤]