硬腭鳞癌的疗效评价和预后因素分析  

Effectiveness Evaluation and Prognostic Factor Analysis in Patients with Squamous Cell Carcinoma of the Hard Palate

作　　者：刘志民[1] 李铨[1] 刘学奎[1] 张欣睿[1] 李浩[1] 杨安奎[1] 郭朱眀 曾宗渊[1] 

机构地区：[1]华南肿瘤学国家重点实验室//中山大学肿瘤防治中心头颈科,广东广州510060

出　　处：《中山大学学报（医学科学版）》2013年第1期148-152,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2009B030801136)

摘　　要：【目的】分析硬腭鳞癌的治疗效果及影响预后的因素。【方法】对1964-2008年在中山大学肿瘤防治中心住院治疗的155例原发于硬腭的鳞癌进行回顾性队列研究。应用Kaplan-Meier法计算累计生存率,各因素间比较用Log-rank检验,多因素分析采用Cox回归分析模型。【结果】本组155例患者总的5年、10年生存率分别为36.3%和26.3%。手术及手术为主的综合治疗组(单纯手术治疗、手术+放疗、手术+化疗、手术+放疗+化疗)与非手术治疗组(单纯放疗、单纯化疗、放疗+化疗)5年生存率分别为44.7%和24.3%(P=0.002)。多因素分析结果表明:切缘阳性和临床分期为晚期的患者预后差(P<0.05)。【结论】手术治疗或以手术为主的综合治疗是硬腭鳞癌的首选治疗方法。切缘情况和临床分期是影响硬腭鳞癌预后的独立因素。[ Objective ] To evaluate the efficacy of treatment and investigate the prognostic factors of squamous cell carcinoma of the hard palate. [Methods] A total of 155 cases of squamous cell carcinoma of the hard palate hospitalized in Cancer Center, Sun Yatsen University, from 1964 to 2008 were reviewed retrospectively. The cumulative survival rate was analyzed by Kaplan-Meier method. The factors were compared using the log-rank test. The influencing factors were screened by Cox proportional hazards model. [ Results ] The 5- and 10-year overall survival rates were 36.3% and 26.3%, respectively. The 5 years disease-specific survival rates for the patients treated with surgery or surgical comprehensive treatment group and non-operative treatment group were 44.7% and 24.3% （P = 0.002）, respectively. Multivariate analysis showed that margin positive and advanced stage were independently associated with decrease survival rates （P 〈 0.05）. [ Conclusion] Surgery or surgery dominated multi-modality therapy was the principal treatment modality for squamous cell carcinoma of the hard palate. Margin and clinical stage are independent factors affecting the prognosis.

关 键 词：硬腭肿瘤 鳞癌 综合治疗 预后 

分 类 号：R739.83[医药卫生—肿瘤]