E-选择素基因多态性与脑梗死相关性研究  

Association study between a polymorphism of E-selectin gene and cerebral infarction

作　　者：袁冬[1] 阚春燕[1] 高鹏[2] 杜丹华[1] 吴江[1] 

机构地区：[1]吉林大学白求恩第一医院神经内科,吉林长春130021 [2]吉林大学白求恩第一医院内分泌科,吉林长春130021

出　　处：《中风与神经疾病杂志》2013年第3期208-210,共3页Journal of Apoplexy and Nervous Diseases

基　　金：卫生部临床重点项目

摘　　要：目的探讨E-选择素(E-selectin)及基因A561C多态性与脑梗死相关性。方法以rs5361位点为遗传标记,采用聚合酶链反应(PCR)和限制性片段长度多态性(RFLP)检测199例脑梗死组和124例对照组人群E-selectin基因的多态性。结果脑梗死组与对照组的rs5361位点的等位基因和基因型频率在两组中比较,差异均有统计学意义(P<0.05);相对风险度分析,C等位基因携带者患脑梗死的风险是A等位基因的5.4倍。脑梗死组AC+CC基因型频率明显高于对照组(P=0.00)。结论 E-selectin基因A561C多态性与脑梗死的发病相关,C等位基因可能是脑梗死发生的危险因素之一。Objective To detect the E-selectin and A561C gene polymorphism in patients with cerebral infarction. Methods Genotypes of E-selectin in 199 patients with cerebral infarction and 124 controls were typed by PCR - RFIP, SNPrs5361. Results There was significant difference in frequencies of allele and genotype in E-selectin A561C polymor- phism between patients group and control group（ P 〈 0.05 ）. Relative risk analysis indicated that the risk of cerebral infarc- tion in C allele was 5.4 times higher than that in A allele. And the frequency of AC ＋ CC genotypes in patients group was significant higher than control group（ P = 0.00）. Conclusion E-selectin A561C polymorphism was associated with cere- bral infarction, and C allele might be a risk factor of cerebral infarction.

关 键 词：E-选择素 脑梗死 基因多态性 

分 类 号：R743.3[医药卫生—神经病学与精神病学]