亚急性联合变性病程不同时期MRI上病灶出现率及临床表现的差别  

Differences of abnomal MRI and clinical manifestations in different periods of Subacute combined degeneration in different periods on the rate of abnomal MRI and clinical manifestations

作　　者：姜明[1] 胡洪涛[1] 闫欣[1] 庞英[1] 阎立荣[1] 马志刚[1] 郭笑磊[1] 陈捷[1] 韩仰同[1] 秦朝晖[1] 唐澍[1] 高倩[1] 尤小凡[1] 

机构地区：[1]北京积水潭医院神经内科,北京100035

出　　处：《中风与神经疾病杂志》2013年第3期222-225,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的探讨亚急性联合变性(SCD)在病程不同时期MRI上病灶出现率及临床表现的差别。方法根据病程将SCD患者分为两组,一组病程<6m,一组病程>6m,比较两组患者MRI上病灶出现率及临床表现的差别。结果本组SCD患者共30例,其中11例在MRI上发现病灶,病灶出现率为36.7%,病程<6m时,MRI病灶出现率为55.6%(10/18),病程>6m时,MRI病灶出现率为8.3%(1/12),差异有统计学意义(P<0.05);首发症状为四肢麻木有16例,占53.3%,其中病程<6m 9例(50.0%),病程>6m 7例(58.3%),差异无统计学意义(P>0.05);首发症状为行走不稳有9例,占30.0%,其中病程<6m有3例(16.7%),病程>6m有6例(50.0%),差异无统计学意义(P>0.05);病程中出现二便障碍有11例,占36.7%,其中病程<6m 2例(11.1%),病程>6m 9例(75.0%),差异有统计学意义(P<0.01)。结论 SCD在病程早期,MRI上更易发现病灶;病程晚期,更易出现二便障碍。Objective To investigate the differences of abnomal MRI and clinical manifestations in different periods of subacute combined degeneration （SCD） in different periods on the rate of abnomal MRI and clinical manifestations. Methods The patients were divided into two groups according to weather more than 6 months or not. The differences of SCD in different periods on the rate of abnomal MRI and clinical manifestations were compared. Results In a total of 30 cases of the SCD patients, 11 cases of lesions were found on MRI with the rate of 36.7%. The rate of lesions on MRI was 55.6% when history less than 6 months, but 8.3% when history more than 6 months. The difference was statistically signif- ieant（P 〈0.05）. There were 16 cases which had numbness of the limbs as the first symptom with the rate of 53.3%. There were 9 Cases when as history less than 6 months（50.0% ） ,but 7 cases as historywhen more than 6 months（58.3% ）. The difference was not statistically significant（P 〉 0.05 ）. There were 9 cases which had gait ataxia as the first symptom with the rate of 30.0%. There were 3 cases when as history less than 6 months（ 16.7% ） ,but 6 cases when as history more than 6 months（ 50.0% ）. The difference was not statistically significant（ P 〉 0.05 ）. There were 11 cases with sphincter disturbances in the course of the disease. The rate was 36.7%. There were 2 cases when history less than 6 months （ 11.1% ） ,but 9 cases when history more than 6 months（75.0% ）. The difference was statistically significant（P 〈0.01 ）. Conclusion More lesions on MRI were found in the early period of SCD. The incidentce of sphincter disturbances was higher in late SCD.

关 键 词：亚急性联合变性 磁共振成像 

分 类 号：R744.6[医药卫生—神经病学与精神病学]