一个阿尔茨海默病大家系报告  

A multiple of Alzheimer pedigrees report

作　　者：李强明[1] 臧贵勇[1] 杨明[2] 李秧秧[1] 

机构地区：[1]贵阳医学院人体解剖学教研室,贵州贵阳550001 [2]贵阳医学院生物学教研室,贵州贵阳550001

出　　处：《中风与神经疾病杂志》2013年第3期253-256,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的确诊该家系所患疾病是否为家族性阿尔茨海默病。方法详细调查该家系成员临床资料,制作家系图谱,结合该家系成员临床资料诊断该疾病。对先证者脑组织进行HE染色、Bodian银染色、免疫组化检测。结果在先证者脑组织的额、颞、顶、枕、海马发现大量典型老年斑(Senile plaques,SP)和神经原纤维缠结(Neurofibrillary tangles,NFT)。结论该家系是一个具有典型病理特征的阿尔茨海默病家系。Objective AIM：This study is to confirmed the a family members suffereding from the disease is familial Alzheimer＇ s disease. Methods ETHODSs： Detailed clinical data of the family members were obtained, to investigate members of the family, the production of pedigree of the the clinical data of family members of the clinical data were ob- tained to diagnose the disease. The proband＇ s brain tissue HE staining, Bodian silver staining and, immunohistoehemistry were useddetected by immunohistochemistry. Results ESULTS：In the proband＇ s brain tissue, found a large number of typical senile plaques （Senile plaques, SP ）and neurofibrillary tangles （Neurofibrillary tangles, NFT）were found in the proband＇s brain tissueand neurofibrillary tangles （Neurofibrillary tangles, NFT）. Conclusion The family is possess thea typical pathological features of Alzheimer pedigrees.

关 键 词：阿尔茨海默病 老年斑 神经元纤维缠结 

分 类 号：R749.16[医药卫生—神经病学与精神病学]