血清IGF-II和TGF-α水平变化在结直肠癌中的临床意义  

The clinical significance of serum IGF-Ⅱ and TGF-α levels in the colorectal neoplasms

作　　者：郝敬鹏[1] 

机构地区：[1]天津医科大学第二医院肛肠外科,天津300211

出　　处：《中国现代医学杂志》2013年第1期48-51,共4页China Journal of Modern Medicine

摘　　要：目的通过检测结直肠癌患者血清中IGF-Ⅱ(Insulin-like Growth FactorⅡ,胰岛素样生长因子I-I)和TGF-α(Tranceforming Growth Factorα,转化生长因子α)水平的变化来研究其在结直肠癌早期诊断,进展程度及预后评价中的价值。方法采用放免分析法分别检测了68例结直肠癌患者、22例结直肠腺瘤患者术前、术后3个月和20例正常对照者血清中IGF-Ⅱ和TGF-α的水平,并检测其中68例于术后1年接受随访的结直肠癌患者(其中7例复发者)血清中该两种物质的水平。结果结直肠癌患者血清IGF-Ⅱ和TGF-α水平显著高于结直肠腺瘤组和正常对照组,结直肠腺瘤组显著高于正常对照组;术后3个月接受随访的90例患者该两种物质水平显著低于术前,接近正常水平;Dukes C期患者血清中该两种物质水平显著高于A期、B期,但A期、B期之间无明显差异;术后1年接受随访的68例患者,复发组血清中该两种物质水平显著高于非复发组。结论血清中IGF-Ⅱ和TGF-α水平变化可较灵敏地反映结直肠癌患者病情的变化,可以作为患者早期诊断,进展程度及预后评价的指标。[ Objective ] To study the value of early diagnosis, progression and prognosis of the colorectal neo- plasms through testing the changes of serum IGF- II and TGF-α in eoloreetal neoplasms patients. [ Methods ] ex- amined the levels of serum IGF- II and TGF-α of 68 cases of patients with eoloreetal neoplasms, 22 cases of pa- tients with colorectal adenomas preoperative and postoperative 3 months and 20 cases of normal controls by ELISA. [ Results ] The serum IGF- II and TGF-α in eolorectal neoplasms patients are obviously higher than eoloreetal ade- nomas group and normal controls, colorectal adenomas group are obviously higher than that of normal control group; the levels of this two kinds of material are obviously lower in the 90 follow-up patients than that had been operated three months before, and they are close to the normal levels. The serum levels of this two kinds of material in Dukes C patients are obviously higher than Dukes A and B, but that are not obvious different between Dukes A and B; the serum levels of this two kinds of material of the recurrence group are obviously higher than that of the group without recurrence in the 68 follow-up patients that had been operated one year before. [ Conclusion ] the changes of the Serum IGF- H and TGF-α can be more sensitive to reflect the condition changes of eoloreetal neoplasms patients, can serve as markers of early diagnosis, progression and prognosis in colorectal neoplasms.

关 键 词：结直肠癌 IGF-II TGF-Α 早期诊断 预后 复发 

分 类 号：R735.34[医药卫生—肿瘤]