西酞普兰治疗脑梗死后病理性哭泣的临床疗效  

The clinical study of citalopram on affective disorder after cerebral infarction

作　　者：衣旭华 龙君[1] 刘丽娟[1] 殷军蕾 郭俊峰[1] 

机构地区：[1]威海市立医院南院区神经康复中心,威海264200

出　　处：《中华行为医学与脑科学杂志》2013年第2期144-146,共3页Chinese Journal of Behavioral Medicine and Brain Science

摘　　要：目的观察西酞普兰治疗脑梗死后病理性哭泣的疗效。方法脑梗死后病理性哭泣106例，以投币法随机分为两组，西酞普兰治疗组54例，对照组52例，对照组给予常规脑血管病治疗，治疗组在此基础上加用西酞普兰10～20rag，1次／日，连服3月，比较两组治疗后总有效率、起效时间和长谷川痴呆量表积分。结果治疗组和对照组总有效率分别是94．4％和38．5％；起效时间分别是（1．98±1．24）d和（78．00±17．95）d；痴呆量表积分分别是（8．43±2．21）分和（6．24±2．02）分，两组的差异均有统计学意义（P〈0．01）。结论西酞普兰治疗病理性哭泣效果好，起效快，不但能有效控制哭泣发作，而且能显著提高患者的认知功能。Objective To investigate efficacy of citalopram on pathological crying after cerebral infarc-tion. Methods 106 patients with pathological crying after cerebral infarction were randomly divided into two groups,treatment group（54 cases） and control group（52 cases）. Control group received conventional treatment of cerebrovaseular disease. Treatment group taken citalopraml0-20mg orally one time per day for three months based on conventional treatment. The total response rate, effectual time, and Hasegawa Dementia Scale （HDS） scores were compared between two groups after treatment. Results There were significant differences in total response rates （94.4% and 38.5% ,respectively） ,effectual time（ 1.98 ± 1.24 and 78 ± 17.95 ,respectively） and HDS（ 8.43 ±2.21 and 6.24 ± 2.02, respectively） between treatment group and control group （P 〈 0.01 ）. Conclusion The study suggests that it is effective to treat pathological crying with eitalopram and its effect is quick. Citalopram can not only control patient~ pathological crying,but also improve cognitive function.

关 键 词：脑梗死 病理性哭泣 治疗 西酞普兰 

分 类 号：R749.4[医药卫生—神经病学与精神病学]