LKB1在子宫内膜样腺癌中的表达及意义  

Expression and Clinical Significance of LKB1 in Endometrial Carcinomas

作　　者：李爱琳[1] 柏兴华[1] 邓博雅[2] 姜彦多[3] 李光[1] 

机构地区：[1]中国医科大学附属第一医院放疗科,沈阳110001 [2]中国医科大学附属第一医院妇科,沈阳110001 [3]中国人民解放军第二零二医院病理科,沈阳110003

出　　处：《中国医科大学学报》2013年第3期221-224,共4页Journal of China Medical University

基　　金：辽宁省科学技术计划项目(201102297)

摘　　要：目的探讨抑癌基因LKB1在子宫内膜样腺癌及正常组织中的表达差异及其与肿瘤临床病理因素和微血管密度的关系。方法应用免疫组化方法检测LKB1在50例子宫内膜样腺癌和30例子宫内膜单纯性增生组织中的表达,并通过检测CD34在子宫内膜样腺癌的表达确定肿瘤微血管密度。结果 LKB1在子宫内膜样腺癌中的表达低于子宫内膜单纯性增生组织(P=0.033);在子宫内膜样腺癌中,LKB1的低表达与肿瘤细胞低分化、肌层浸润≥1/2及高微血管密度相关(P=0.022,P=0.035,P=0.030)。结论 LKB1能够抑制子宫内膜样腺癌的发生、新生血管形成及侵袭。Objective To investigate the expression of tumor suppressor gene LKB1 in endometrial carcinoma and normal proliferative en- dometrium samples, and assess their correlations with clinicopathological parameters and microvessel density. Methods The expression lev- els of LKB1 in normal proliferative endometrium sanlples and endometrial carcinoma samples were measured by immunohistochemistry. The microvessel density was determined using CD34 staining. Results The expression of LKB1 in endometrial carcinoma was significantly low- er than normal proliferative endometrium （P =0.033）. In endometrial cancer,decreased LKB1 expression was significantly related to poor differentiation,myometrial invasion≥1/2 and high microvessel density （P =0.022,P =0.035 and P =0.030,respectively）. Conclusion LKB1 may negatively regulate carcinogenesis, angiogenesis and progression in endometrial carcinoma.

关 键 词：LKB1基因 子宫内膜样腺癌 微血管密度 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]