急性肝衰竭潜在新靶点和中医药的调节  

On a New Action Target,the Liver Oxidative Stress Reaction and Injury,of Anti-acute Hepatic Failure and the Treatment with TCM

作　　者：杨运高[1] 

机构地区：[1]南方医科大学中医药学院,广东广州510515

出　　处：《时珍国医国药》2013年第3期695-697,共3页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81173262)

摘　　要：急性肝衰竭是严重危害人类健康的一种疾病,病死率很高。以往对急性肝衰竭的研究着重在免疫介导的肝损伤或药物引起的肝细胞坏死方面。作者以肝脏的氧化应激损伤为重点,以细胞抗氧化应激的重要分子APE/Ref-1为中心,强调氧化应激损伤在肝脏"二次打击"中的重要性。指出急性肝衰竭的机制复杂,可能存在多种衰竭途径,氧化应激有可能是肝脏二次打击的重要因素,从氧化应激损伤角度有可能为急性肝衰竭治疗提供新的潜在靶点,中医药具有对其进行调节的可能,值得进一步研究探索。Objective Acute hepatic failure brings human health a lot of disadvantages.Its death rate was very high.Immune-mediated liver injury and necrosis of liver cells by adverse drug reaction were Main reason According to the research of acute hepatic failure（AHF） past years.But in this research we think that the liver oxidative stress reaction and injury is closely related to AHF.And we research the changes of oxidative stress reaction and injury and antagonistic action of APE/ Ref-1 in AHF.We observed that the changes of oxidative stress reaction and injury and antagonistic action of APE/ Ref-1 were important in two-hit to AHF,These works will be important to reveal the mechanism of AHF and provide a new idea and new way for therapy of AHF.Traditional Chinese medicine has the potential to regulate AHF by APE/ Ref-1.

关 键 词：急性肝衰竭 氧化应激损伤 APE REF-1 

分 类 号：R2-031[医药卫生—中西医结合]