苦参碱对实验大鼠肝纤维化的影响  

Effect of matrine on experiment rat liver fibrosis

作　　者：陈伟忠[1] 朱梁[1] 张兴荣[1] 蔡雄[1] 张贤康[1] 张俊平[2] 

机构地区：[1]中国人民解放军第二军医大学附属长征医院消化内科,上海200003 [2]中国人民解放军第二军医大学药学院中西药研究室,上海200433

出　　处：《中国新药与临床杂志》2000年第5期410-413,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :研究苦参碱对实验大鼠肝纤维化的防治作用 ,并探讨其可能的机制。方法 :应用四氯化碳诱导大鼠实验性肝纤维化 ,以苦参碱防治。观察3,6 ,12wk时溶剂对照组、四氯化碳组、苦参碱组血清丙氨酸转氨酶 (ALT)、透明质酸 (HA)、肝组织羟脯氨酸 (HyP)含量以及肝脏病理变化。结果 :苦参碱能显著减轻实验大鼠肝细胞变性、坏死及纤维组织的形成 ,同时能降低不同实验阶段血清ALT(P <0 .0 1) ,HA(P <0 .0 1)以及肝组织中HyP含量 (P <0 .0 5)。结论 :苦参碱有保护肝细胞 ,减轻肝细胞坏死 ,防治四氯化碳诱发的肝纤维化的作用。AIM: To study the antifibrogenesis effect of matrine. METHODS: The experimental liver fibrosis induced by tetrachloromethone in rats was treated with matrine. Serum alamine aminotransferase (ALT), hyaluronic acid (HA), hydroxyproline (HyP) in liver tissue and pathological change were observed in soluent compase group, tetrachloromethone group and (matrine group) rats for 3, 6, 12 wk. RESULTS: Elevated serum ALT, HA and HyP in liver tissue markedly decreased, liver necrosis and fibrogenesis were also significantly alleviated when tetrachloromethone treated rats were intragastrally given matrine for the indicated time. CONCLUSION: These results indicate that matrine has protection of hepatic cells hepatocellular death and liver fibrosis induced by tetrachloromethone action.

关 键 词：苦参碱 肝纤维化 实验研究 

分 类 号：R575.2[医药卫生—消化系统] R286.55[医药卫生—内科学]