FAK参与肺癌血管生成的研究进展  

Research advance of FAK in angiogenesis of lung cancer

作　　者：周琼[1] 林春龙[1] 

机构地区：[1]南华大学岳阳市二人民医院呼吸内科,414000

出　　处：《国际呼吸杂志》2013年第4期288-293,共6页International Journal of Respiration

摘　　要：黏着斑激酶（focal adhesion kinase，FAK）是一种非受体型胞浆蛋白酪氨酸蛋白激酶，是细胞内重要的骨架蛋白与多种信号通路的关键分子。FAK参与肿瘤发生的多个环节，如细胞的迁移、存活、增殖、伸展、黏附、侵袭和抗凋亡。近年来FAK已成为潜在的肿瘤治疗靶点研究热点。因此明确FAK在肺癌血管生成、侵袭转移过程的作用机制，对更好地认识FAK作为重要的抗血管生成剂甚至抗肿瘤药物有重要意义。Focal adhesion kinase （FAK） is a non-receptor cytoplasmic tyrosine kinase,which acts as an important intracellular scaffold protein and a major mediator of many signaling pathways. FAK is involved in multiple processes of tumorigenesis, such as cell migration, survival, proliferation, stretch, adhesion, invasion,and anti-apoptosis. Recently,FAK has become a research hotspot of potential target for cancer treatment. Therefore, a clear mechanism of the process of FAK involved in lung cancer angiogenesis, invasion and metastasis is helpful for better understanding of FAK as an important antiangiogenic agent and even anti-cancer drug.

关 键 词：黏着斑激酶 血管生成 肺癌 生长因子 

分 类 号：R734.2[医药卫生—肿瘤]