角膜缘干细胞移植联合丝裂霉素C治疗翼状胬肉临床分析  

Clinical Analysis of Limbal Autograft Transplantation with Mitomycin C Therapy of Pterygium

作　　者：罗立勤[1] 郑利民[1] 杜鹏程[1] 

机构地区：[1]包头医学院第一附属医院眼科,内蒙古包头014010

出　　处：《中国伤残医学》2013年第3期19-21,共3页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的：探讨角膜缘干细胞移植术中联合丝裂霉素C治疗翼状胬肉的治疗效果。方法：对474例（492眼）采用3种不同术式分3组行手术治疗。Ⅰ组：单纯翼状胬肉切除术;Ⅱ组：翼状胬肉切除术＋自体角膜缘干细胞移植术;Ⅲ组：翼状胬肉切除术＋自体角膜缘干细胞移植术＋丝裂霉素C。经过6个月~5年的对比观察。结果：3种术式比较：单纯翼状胬肉切除术92眼,治愈62眼,复发30眼,复发率32.6%;翼状胬肉切除术＋自体角膜缘干细胞移植术119眼,治愈104眼,复发15眼,复发率12.6%;翼状胬肉切除术＋自体角膜缘干细胞移植术＋丝裂霉素C手术281眼,治愈276眼,复发5眼,复发率1.8%。结论：翼状胬肉切除术＋自体角膜缘干细胞移植术＋丝裂霉素C治疗翼状胬肉复发率明显低于其他术式,且术后角、结膜上皮修复快,视力恢复好。Objective：Analyze the clinical efficacy of surgical method to treat pterygium by pterygium excision with limbal autograft transplantation with mitomycin C in the operation. Methods：474 （492 eyes）pterygium patients admitted in our hospital, according to different surgical methods were divided into three groups： Ⅰ group： simple excision of pterygium, Ⅱ group： pterygium excision combined with limbal autograft transplantation, Ⅲ： pterygium excision with limbal autograft transplantation with mitomycin C in the operation, Followed up for 6 months to 36 months.Record postoperative recurrence of pterygium, corneal epithelial healing time and postoperative visual acuity, Statistical analysis of differences results of each surgical method.Results： The comparison of the recurrence rate of different pterygium group： Ⅰ group（92 eyes） had 30 eyes recurrence, the recurrence rate was 32.6%; Ⅱ group（119eyes） had 15 eyes recurrence ,the recurrence rate was 12.6%; Ⅲ group（281 eyes） had 5 eye recurrence, the recurrence rate of 1.8%. After statistical analysis, the recurrence rate among the three groups has significant difference. Conclusions： Pterygium excision with limbal autograft transplantation with mitomycin C in the operation is a better treatment to lower the recurrence rate of pterygium and better improvement visual acuity and corneal epithelial repair.

关 键 词：翼状胬肉 角膜缘干细胞 丝裂霉素C 

分 类 号：R777.33[医药卫生—眼科]