同种异体肋软骨膜游离移植颞下颌关节重建的实验研究  

The experimental study on temporomandibular joint reconstruction using free allogenous costal perichondrial grafts in rabbits

作　　者：孙健[1] 赵文清[2] 胡永升[2] 李宁毅[1] 

机构地区：[1]青岛医学院附属医院口腔颌面外科,266003 [2]西安医科大学口腔医学院

出　　处：《现代口腔医学杂志》2000年第5期295-297,共3页Journal of Modern Stomatology

摘　　要：目的　本研究首次提出了同种异体游离肋软骨膜 (PC)移植再生关节软骨的新方法。方法　通过分阶段取材分析 ,动态观察、分析了同种异体PC再生软骨的情况。结果　同种异体移植的PC可以再生软骨 ,而且再生的软骨与异体移植的软骨一样可以长期存活 ,而未引起明显的急性、慢性及超急排斥反应。结论　游离移植的PC形成的关节软骨比其它一些方法形成的假关节有较多的生理功能 ,属于关节的生物性修复。Objective To reconstruct temporomandibular joint using free allogenous costal perichondrial grafts in rabbits.Methods The growth of newborn cartilage in 120 days following the allograft of free costal PC to the bone section of TMJ condyle was studied.Light microscope,electron microscope,biochemistry analysis,and PCNA immune chemo-staining were used to observe the formation of new catilages tissue structure,GA and collagen content.Results ①The transplanted homologous PC escaped observable immune repulsion so that it could survive to form new joint cartilage with approximate normal tissue structure and biochemistry constitution.②With excellent form structure and biology mechanical functions,the new cartilage was able to meet the requirement of TMJ,and successfully prevent the adhension of the bone section,as well as biologically rebuild TMJ.Conclusion ①Homologous xenografting of free costal PC will not lead to an apparent immunorejection of the host,instead,the grafts can maintain their existence by obtaining nutritions from the surrounding tissue and regenerate cartilage tissue.②Anotomical structure and physiological function of the regenerated TMJ can satisfy the normal needs.

关 键 词：同种异体移植 颞下颌关节重建 软骨膜移植 

分 类 号：R782[医药卫生—口腔医学]