奥沙利铂联合腹腔热灌注治疗胃肠癌的效果观察  

Effect observation of oxaliplatin combined with intraperitoneal hyperthermic perfusion in treatment of gastrointestinal cancer

作　　者：林维凯[1] 

机构地区：[1]福建中医药大学附属第二人民医院普外科,福建福州350001

出　　处：《中国当代医药》2013年第9期64-65,共2页China Modern Medicine

摘　　要：目的探讨奥沙利铂联合腹腔热灌注治疗胃肠癌的临床疗效。方法回顾性分析本院收治的64例胃肠癌患者的临床资料,按治疗方法分为治疗组和对照组各32例,两组患者均采用奥沙利铂、亚叶酸钙、氟尿嘧啶进行化疗,治疗组在药物化疗期间还采用腹腔热灌注化疗。分别记录比较两组患者的疗效评价。结果治疗2个周期后,治疗组的总有效率(RR)为71.88%,显著高于对照组的62.50%,差异有统计学意义(P<0.05),其中治疗组CR10例(31.25%),显著高于对照组的CR8例(25.00%),差异有统计学意义(P<0.05)。结论奥沙利铂联合腹腔热灌注化疗治疗胃癌患者,临床疗效显著。Objective To investigate the clinical efficacy of oxaliplatin combined with intraperitoneal hyperthermic perfusion in the treatment of gastrointestinal cancer. Methods The clinical data of 64 cases of gastrointestinal cancer in our hospital was analyzed retrospectively. They were divided into the treatment group and the contro｜ group, and 32 cases in each group. The two groups were all treated with oxaliplatin, leucovorin, fluorouracil chemotherapy, the treat- ment group was also taken with intraperitoneal hyperthermic perfusion chemotherapy during chemotherapy. The eva!u- ation of the efficacy of the two groups were recorded and compared. Results After two cycles of treatment, the treat- ment group＇s total rate （RR） was 71.88%, which was significantly higher than the control group of 62.50%, the differ- ence was significant （P 〈 0.05）, which CR 10 cases （31.25%） in the treatment group was significantly higher than that in the control group with CR 8 cases （25.00%）, the difference was significant （P 〈 0.05）. Conclusion The clinical effi- cacy of oxaliplatin combined with intraperitoneal hyperthermic perfusion chemotherapy in the treatment of patients with gastric cancer is significant.

关 键 词：奥沙利铂 胃肠癌 腹腔热灌注 效果观察 

分 类 号：R735[医药卫生—肿瘤]