破坏前庭器官对压力感受性反射敏感性的影响  

Effect of labyrinthectomy on baroreceptor reflex sensitivity

作　　者：兰艳[1] 姜宪[1,2] 杨彦召[1] 李丽威[1] 金婧 金元哲[1] 

机构地区：[1]延边大学医学院生理学与病理生理学教研部,长白山生物资源与功能分子教育部重点实验室,吉林延吉133000 [2]延边大学附属医院耳鼻咽喉科,吉林延吉133000 [3]首尔国立大学校医科大学病理学教研室

出　　处：《中国实验诊断学》2013年第3期421-424,共4页Chinese Journal of Laboratory Diagnosis

基　　金：国家自然科学基金资助(31160212)

摘　　要：目的观察双侧迷路破坏对压力感受性反射敏感性的影响。方法清洁级雄性大鼠40只,随机分为正常组、手术组和假手术组。手术组和假手术组又进一步分为双侧迷路破坏组(bilateral labyrinthectomy,BL)和压力感受性反射去除组(sinoaortic denervation,SAD)。通过静脉灌流苯肾上腺素(phenylephrine,PE)和硝普钠(sodium nitro-prusside,SNP)观察压力感受性反射敏感性的变化。结果 (1)BL不影响PE所诱发的压力感受性反射敏感性,但是使SNP所诱发的压力感受性反射敏感性降低;(2)SAD后大鼠失去调节PE所诱发的急性高血压的能力,而减弱对SNP所诱发的急性低血压的调节能力。结论压力感受性反射和前庭系统可能共同参与急性低血压时血压的调节。Objective To investigate the effect of labyrinthectomy on baroreceptor reflex sentivity. Methods Forty adult male Wistar rats were divided into three groups： normal intact group, sham-operated group and operated group. The sham-operated group and operated group were subdivided into bilateral labyrinthectomy （BL） group and sinoaortic denervation （SAD） group. To investigate the changes of baroreflex sensitivity by increasing arterial pressures with ramp infusions of phenylephrine （PE） and by lowering BP with sodium nitroprusside （SNP）. Results （1） BL didn＇t affect the sensitivity of PE-induced baroreflex ,but weak- ened the baroreflex sensitivity during intravenous infusion of SNP. （2） SAD made the baroreceptor reflex loss the regulation ability of PE-induced hypertension and attenuated the sensitivity induced by injected SNP. Conclusion Both the baroreflex and the ves- tibular system cooperate to maintain AP during SNP-induced hypotension.

关 键 词：迷路破坏 压力感受性反射去除 压力反射敏感性 

分 类 号：R363[医药卫生—病理学]