海洛因对大鼠胚胎发育的影响  

Effect of Heroin on Embryonic Development in Rats

作　　者：谢明仁[1] 张璟 俞文[1] 俞发荣[1] 

机构地区：[1]甘肃政法学院 甘肃省证据科学技术与应用重点实验室,甘肃兰州730070 [2]甘肃省疾病预防和控制中心,甘肃兰州730000

出　　处：《甘肃科学学报》2013年第1期42-44,共3页Journal of Gansu Sciences

基　　金：甘肃省自然科学基金(GC 2010-148);甘肃省高校学科带头人扶持项目计划基金(GJ 2011-23);甘肃省证据科学技术研究与应用重点实验室科技计划项目基金(ZDSYS-Y17);甘肃政法学院科研资助重点项目(GZF2011XZDLW29)

摘　　要：为探讨海洛因对大鼠胚胎发育的影响.研究雌性Wistar大鼠受孕后的不同时间给予不同剂量的海洛因,于妊娠第20天,剖腹观察胚胎发育的情况.结果表明:给予海洛因20mg/kg组胎鼠中脑导水管和左右脑室增宽,大脑半球、腰椎骨、肋骨、肢掌骨发育不全,胎鼠侧脑室扩大、大脑皮质、颞叶、双侧被盖区及结合臂发育不全,枕骨缺如,脑膨出,椎骨裂开,肋骨骨化不全,四肢远端骨未骨化;30mg/kg组未见胚胎形成.结果表明:海洛因对大鼠胚胎脑及骨骼发育有明显的毒性作用,致畸程度随给药剂量增加而增大.Our Objective was to investigate the effect of heroin on embryonic development in rats.Female Wistar rats after conception for different times were given different doses of heroin and on the 20th day,they were dissected to observe their embryonic development.It was shown that given heroin 20 mg/kg the midbrain aqueduct and ventricles of the fetal rat got widened;its cerebral hemispheres,lumbar vertebrae,ribs and limb metacarpals were not fully developed;its lateral ventricle got enlarged;its cerebral cortex,the temporal lobe,the bilateral cap and combined arms were in hypoplasia;its occipital encephalocele was absent,its vertebrae and ribs cracked;the ossification of its ribs was incomplete and the distant bones of the limbs were not yet ossified.With the dose of heroin 30 mg/kg no embryo was found.It was concluded that heroin had apparent toxic effects on embryonic rat’s brain and bone development.As the dose increases,the teratogens got more serious.

关 键 词：海洛因 胚胎 大鼠 

分 类 号：R749.61[医药卫生—神经病学与精神病学]