复方血栓通胶囊基于血液循环和凝血过程相关靶点的网络药理学研究  

Network Pharmacology Study of Compound Xueshuantong Capsule Based on the Targets Related to Blood Circulation and Hemostasis

作　　者：刘忠政[1] 梁洁萍[1] 聂怡初[1] 刘宏[1] 谢称石 程国华[3] 苏薇薇[1] 

机构地区：[1]中山大学生命科学学院,广东广州510275 [2]广东众生药业股份有限公司,广东东莞523325 [3]暨南大学药学院,广东广州510632

出　　处：《中山大学学报（自然科学版）》2013年第2期97-100,共4页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家"重大新药创制"科技重大专项资助项目(2011ZX09201-201-22);国家科技支撑计划课题资助项目(2012BAT29B09);东莞医疗卫生单位科技计划资助项目(2012105102004)

摘　　要：利用基于计算机分子对接的网络药理学方法,研究复方血栓通胶囊化学成分对血液循环和凝血过程相关靶点的作用,并得到了成分对靶点的作用网络图。研究表明复方血栓通胶囊化学成分对ACE、PDE等多个靶点起作用。研究为在分子水平上揭示复方血栓通胶囊治疗视网膜静脉阻塞的多靶点调控机制提供了依据。Network pharmacology based on the computational molecular docking was used to study inter-action of chemical composition of Compound Xueshuantong Capsule to the targets related to blood circula-tion and hemostasis. A compound-target interaction network diagram was generated. The results showed that the chemical compounds of Compound Xueshuantong Capsule interacts with the multiple targets, such as ACE and PDE, revealing the multitargeted regulatory mechanism of Compound Xueshuantong Capsules in the treatment of retinal vein occlusion on molecular level.

关 键 词：复方血栓通胶囊 网络药理学 分子对接 

分 类 号：R96[医药卫生—药理学]