糖自氧化及抗氧化剂对其抑制作用的研究进展  

Progress of the Study on the Relationship between Sugar Autoxidation, Disease and Antioxidants

作　　者：贾曼[1] 陈华[1] 陈际达[1] 夏之宁[1] 

机构地区：[1]重庆大学化学化工学院,重庆400044

出　　处：《化学通报》2013年第3期231-237,共7页Chemistry

基　　金：国家自然科学基金项目(21005092);科技部国际合作计划项目(2010DFA32680)资助

摘　　要：近年来随着自由基医学和自由基生物学的发展,大量研究表明,慢性疾病导致的并发症与自由基损伤有着密切的关系。糖尿病作为典型的慢性疾病之一,主要是由于体内血糖浓度过高,糖自氧化产生的自由基增多和蛋白质的非酶修饰,即非酶糖基化加剧,引起的。本文对近年来人体内的还原性单糖的自氧化研究做一总结,以期对开发和筛选针对因糖自氧化或糖基化引起的自由基损伤而导致的疾病的药物有促进作用。文中主要包括:糖的一些基本生物化学信息,糖自氧化现象在疾病尤其是慢性疾病并发症中的作用及其致病原因,过渡金属对糖自氧化的催化作用,抗氧化剂对体内糖自氧化和糖基化现象的影响等内容。As the development of free radical medicine and free radical biology, researches have proved that chronic diseases are closely related to the damage of free radicals. The free radicals produced by sugar autoxidation and non-enzymatic glycosylation of proteins under hyperglycemia condition may be the main reason for diabetic complications. This paper focuses on the effect of the autoxidation of reductive sugar including the basic information of sugars, the catalysis of transition metal on sugar autoxidation, and the damage for hioaetive molecules from the products which generated from sugar oxidation on chronic diseases in vivo. The researches had demonstrated that some antioxidants can reduce sugar autoxidation and non-enzymatic glycosylation in vivo. This inhibition behavior had been described in brief. The authors hope to offer new insight for R＆D of medicines for the chronic diseases caused by free radical damage from sugar autoxidation and glycosylation of proteins.

关 键 词：糖 自氧化 自由基 非酶糖基化 抗氧化剂 

分 类 号：R96[医药卫生—药理学]