Miconazole对破骨细胞在羟基磷灰石涂层吸收的影响  

The effect of miconazole on the resorption ability of osteoclast on hydroxyapatite coating

作　　者：孟波[1] 刘娟[1] 陈奕帆[1] 吴王喜[1] 

机构地区：[1]广东省口腔医院,南方医科大学附属口腔医院,510280

出　　处：《中国口腔种植学杂志》2013年第1期12-14,共3页Chinese Journal of Oral Implantology

基　　金：国家自然科学基金资助(81100780)

摘　　要：目的:研究钙离子通道抑制剂miconazole对破骨细胞对羟基磷灰石涂层的吸收的影响。方法:在羟基磷灰石涂层表面诱导破骨细胞,破骨细胞形成后,分别加入不同浓度的miconazole细胞培养基,培养48h后,扫描电镜观察羟基磷灰石表层的吸收陷窝。结果:miconazole可抑制破骨细胞的羟基磷灰石涂层的吸收陷窝面积,且吸收陷窝面积随着miconazole浓度的增加而增加。结论:miconazole可抑制破骨细胞对羟基磷灰石涂层的吸收。Objective： To research the effect of miconazole on the osteoclastic resorption ability on hydroxyap- atite （HA） coating surface. Methods： Osteoclasts were generated on HA coating surface. After osteo- clasts were generated, different concentrations of miconazole was added and cocuhured for 48h. The re-sorptlon pits on the surface was measured by SEM and the resorption area were measured. Results： Mi- conazole inhibited resorption area on HA coating surface in a dose dependent manner. Conclusion： Mi- conazole inhibited osteoclastic resorpiton on HA coating surface.

关 键 词：MICONAZOLE 破骨细胞 羟基磷灰石涂层 钙离子通道 

分 类 号：R783.6[医药卫生—口腔医学]