帕瑞昔布钠对术后曲马多静脉自控镇痛的影响  

The Effect of Parecoxib Sodium on Postoperative PCIA Analgesia with Tramadol

作　　者：钮峥嵘[1] 喜燕[2] 

机构地区：[1]新疆维吾尔自治区人民医院麻醉科,新疆乌鲁木齐830001 [2]新疆维吾尔自治区人民医院泌尿一科,新疆乌鲁木齐830001

出　　处：《医学信息》2013年第6期281-282,共2页Journal of Medical Information

摘　　要：目的比较术前静脉注射帕瑞昔布钠对妇科手术术后不同浓度曲马多静脉自控镇痛的影响。方法纳入择期行开腹子宫切除术的60例患者，随机分为3组即A、B、C组，每组20例。术前30min给予每例患者静脉注射帕瑞昔布钠40mg，并且在手术结束时给予静脉注射曲马多1mg／kg。A、B、C三组患者术后静脉自控镇痛泵中各添加曲马多10mg／kg，12mg／kg及14mg／kg。观察每组患者术后12h和24h患者镇痛泵的总按压次数，术后2、4、6、12和24h的疼痛强度（VAS评分）。结果B、C组患者在12h及24h内镇痛泵的总按压次数与A组比较差异有统计学意义（P〈0．05）；B、C组患者在6h、12h及24h时点的VAS评分与A组比较差异有统计学意义（P〈0．05）。结论术前给予帕瑞昔布钠40mg，术后采用静脉注射1mg／kg曲马多及12mg／kg曲马多配置剂量的静脉自控镇痛能够得到良好的镇痛效果。Objective To compare the effect of preoperative intravenous parecoxib sodium on PCIA with different tramadol concentration. Methods 60 patients undergoing elective abdominal hysterectomy were included and randomly divided into three groups with 20 cases each.All patients received parecoxih sodium 40 mg 30 min before operation,intravenous analgesic drug load ＋PCIA was given to all patients.Each patient was given intravenous tramadol lmg/kg at the end of surgery,and postoperative PCIA pump with 10mg/kg, 12mg/kg, 14mg/kg tramadol are givens to the patients of group A, B, C.The total number of pressing of 12h and 24 h of analgesia pump, and 2,4,6,12 and 24 h pain intensity （VAS score）, Prince Henry score （PHS） , Sedation score （SS） and adverse reactions within 24h were recorded. Results The times of analgesia pump pressing in 12h and 24h in B group and group C were statistically lower than in A group （P 〈0.05）;the VAS score for 6h, 12h and 26h time point in group B and C were statistically lower than in A group （P 〈0.05）. ConcLusion Preoperative intravenous parecoxib sodium 40mg, postoperative intravenous lmg/kg tramadol and PCIA with 12mg/kg tramadol are able to get a good analgesic effect in gynecological surgery and reduce the incidence of postoperative adverse reactions.

关 键 词：帕瑞昔布钠 曲马多 多模式镇痛 静脉自控镇痛 

分 类 号：R737.9[医药卫生—肿瘤]