尼古丁镇痛作用机制的研究进展  

The advance in mechanisms of analgesic effect of nicotine

作　　者：刘献文[1] 张宗旺[2] 

机构地区：[1]徐州医学院江苏省麻醉学重点实验室,221002 [2]聊城市人民医院麻醉科

出　　处：《国际麻醉学与复苏杂志》2013年第4期368-370,378,共4页International Journal of Anesthesiology and Resuscitation

摘　　要：背景烟草危害是当今世界最严重的公共卫生问题之一。目前我国约有吸烟者3．5亿，占全球吸烟总人数的1／3，其中成年男性吸烟率为66．0％，女性为3．08％。吸烟成瘾实质上就是尼古丁依赖，尼古丁依赖患者罹患各种慢性疼痛疾病的比例增高。临床和动物实验发现尼古丁具有镇痛作用。目的了解尼古丁具有镇痛作用的神经生物学机制及其研究进展。内容尼古丁镇痛作用是通过乙酰胆碱受体（nAChRs）介导的，作用于α4β2AChR受体通过脊髓上机制发挥镇痛作用；作用于α7nAChR通过胆碱能抗炎反射，进而影响小胶质细胞的迁移、增殖和活化等来发挥镇痛作用。趋向研究尼古丁镇痛作用和尼古丁依赖戒断后机体疼痛生理的变化机制，为吸烟患者的疼痛治疗研究奠定基础。Background The danger of tobacco is one of the world＇s most serious public health problem. At present there are about 350 million smokers in China, accounting for 1/3 of the total smokers worldwide, in which aduh male smoking rate is 66.0%, 3.08% for women. Tobacco addiction is essentially nicotine dependence. Nicotine dependence increases the proportion of patients suffering from chronic pain diseases. Clinical and animal studies found that nicotine has analgesic effects. Objective To understand the neurobiological mechanisms of analgesic effects of nicotine and their research progress. Content Analgesic effects of nicotine are mediated by nAChR, α4β2 nAChRs play analgesic effects by supraspinal mechanisms,α7 nAChRs play a role in cholinergic anti-inflammatory reflection, thereby affecting migration, proliferation and activation of microglia, then play an analgesic effect. Trend Studying on analgesic effects of nicotine and the change s of physiological mechanisms in pain after nicotine dependence-abstinence lays the Foundation for research on treatment of pain in patients with smoking.

关 键 词：吸烟 尼古丁 小胶质细胞 

分 类 号：R[医药卫生]