微核试验评价辣椒素潜在的致突变性和抗突变性的研究  

Micronucleus test for assessment of mutagenic and anti-mutagenic potential induced by capsaicin

作　　者：欧阳永长[1] 马泽兰[1] 黎银燕[1] 杨艮洁[1] 吴译[1] 黎惠英[1] 叶倩媚[1] 陈至真[1] 

机构地区：[1]广州医学院生物技术系,广东广州510182

出　　处：《广州医学院学报》2012年第5期9-11,共3页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨辣椒素潜在的致突变和抗突变作用。方法:通过小鼠的微核实验,检测不同剂量辣椒素的致突变性和辣椒素对环磷酰胺的抗突变作用。结果:高剂量(600～1600μg/kg)辣椒素可显著增加小鼠微核的发生(P<0.05);环磷酰胺(400μg/kg)诱导微核生成的作用明显;低剂量(50～400μg/kg)辣椒素明显降低由环磷酰胺引起的微核率(P<0.01)。结论:低剂量辣椒素具有抗突变、防癌作用。Objective：To determine the mutagenic and anti-mutagenic potential of capsaicin. Methods： We, based on micronucleus test in mice, sought to assess the mutagenic potential of capsaicin at various concentrations and anti-mutagenicity against cyclophosphamide. Results： High-dose capsaicin （ 600-1600μg/kg ） led to genesis of micronucleus in mice（ P 〈 0.05 ）, which appeared more significant when induced by cyclophosphamide （400 μg/kg）. Low-dose （50-400μg/kg） capsaicin considerably reduced the rate of nucleus genesis induced by eyclophosphamide （P 〈 0.01 ）. Conclusion： Low-dose capsaicin could be ingested owing to the anti-mutagenic potential.

关 键 词：辣椒素 微核试验 致突变 抗突变 

分 类 号：R282.7[医药卫生—中药学]