神经细胞黏附分子L1在胶质瘤干细胞中的功能研究  

Advances in research of the functional roles of neural cell adhesion molecule L1 (L1CAM) in glioblastoma stem cells

作　　者：唐丹阳[1] 赵炜疆[1] 

机构地区：[1]汕头大学医学院神经科学中心,广东汕头515041

出　　处：《中国神经肿瘤杂志》2012年第4期282-285,共4页Chinese Journal of Neuro-Oncology

基　　金：国家自然科学基金(No.81171138)

摘　　要：神经细胞黏附分子L1(neural cell adhesion molecule L1,L1CAM)在神经系统发育过程中发挥关键性作用,其功能包括细胞黏附、细胞迁移、细胞生存、轴突的导向以及髓鞘形成。近年来,在多种肿瘤细胞中检测到L1CAM的异常表达,其中包括恶性胶质母细胞瘤(glioblastoma,GBMs)以及胶质瘤干细胞(glioblastoma stemcells,GSCs)。L1CAM在肿瘤细胞上的异常表达,不仅可促进肿瘤的形成和迁移,还可阻碍肿瘤细胞凋亡以及增强肿瘤细胞的抗药性。然而,由于GSCs的存在,使得GBMs治疗难以根治且术后容易复发。L1CAM在GSC中的高表达为我们研究GBMs发病及治疗提供了重要线索。对此,本文对近年来L1CAM和GSCs有关的研究做一综述,并展望L1CAM抗体在治疗GBMs上的前景。Neural cell adhesion molecule L1 （L1CAM） play an important role in neuronal interactions during ontogeny, including migration, survival, axon guidance and synaptic targeting. In recent years, L1CAM has been detected in a variety of cancer cells, including glioblastoma （GBMs） and glioblastoma stem cells （GSCs）. Aberrant expression of L1 has emerged as a critical factor in the development of human carcinomas, where it enhances cell proliferation, motility and chemoresistance. However, aggressively invasive GBM cancer ceils has potent capacity of GSCs, when it＇s into the brain tissue. This prevents complete surgical resection and contributes to therapeutic resistance, thus leading to fatal tumor recurrence. So, the development of more effective treatments requires new insight into the mechanisms underlying the GSCs. L1CAM is differentially overexpressed in GSCs, which provides a pivotal platform for uncovering the functions of LICAM in GSCs, and L1CAM may represent a cancer stem cell specific therapeutic target for improving the treatment of malignant glioblastoma. Therefore, this review summarizes the research of L1CAM in GSCs in recently years, and the prospect of the application of the antibody against L1CAM as a useful means for GSCs treatment.

关 键 词：神经细胞黏附分子 胶质瘤干细胞 恶性胶质瘤 治疗 

分 类 号：R739.41[医药卫生—肿瘤]