血管性帕金森综合征患者血浆β-内啡肽的变化及其临床意义  

Study on the change and its clinical significance of β-endorphin in plasma in patients with vascular Parkinson's syndrome

作　　者：张巍[1] 雷征霖[1] 张延军[2] 谷玲[2] 李敬[2] 蔡新霞[2] 张华丽[2] 杨春[2] 张万琴[3] 

机构地区：[1]大连医科大学第一临床学院神经内科,116011 [2]大连医科大学第一临床学院放免室,116011 [3]大连医科大学基础部生理教研室

出　　处：《临床神经病学杂志》2000年第4期213-215,共3页Journal of Clinical Neurology

摘　　要：目的　探讨血管性帕金森综合征 (VP)患者血浆β-内啡肽 (β- EP)的变化及其临床意义。方法　采用放射免疫法 (RIA)检测 42例 VP、35例帕金森病 (PD)、30例多发性脑梗死 (MCI)患者及 30名正常对照者血浆β- EP含量并对照分析。结果　 1VP与 PD组血浆β- EP含量较 MCI及正常对照组明显降低 (P<0 .0 5 )。 2 VP组血浆β- EP含量降低不如 PD组明显 ,但差别不明显 (P>0 .0 5 )。 3高龄、病情重、伴痴呆和抑郁的 VP患者 ,血浆β- EP含量降得更明显 (P<0 .0 5 )。 4MCI组血浆β- EP含量较正常对照组低 ,差别亦不明显 (P>0 .0 5 )。结论　 VP患者血浆β- EP含量明显降低 ,其机理可能与基底节区 MCI导致多巴胺系统功能降低、慢性脑血管病脂质过氧化和自由基损伤、免疫功能异常、应激能力减弱和炎症反应有关。其意义在于判断病情程度、监测疾病进展、估计预后及指导治疗。Objective To investigate the change and its clinical significance of β endorphin (β EP) in plasma in patients with vascular Parkinson's syndrome(VP).Methods We detected the concentration of β EP in plasma by radioimmunoassay (RIA) in 42 patients with VP,35 patients with Parkinson's disease (PD),30 patients with multiple cerebral infarction(MCI)and 30 normal controls.Results ①The concentration of β EP in plasma in VP and PD groups was all significant lower than that of MCI and normal control groups ( P <0 05). ②The decline of concentration of β EP in plasma in VP group was less than that of PD group, but there wasn't significant difference ( P >0.05). ③The concentration of β EP in plasma dropped more evidently in those VP patients who were advanced age,severe,demential and depressive ( P <0.05). ④The concentration of β EP in plasma of MCI group was lower than that of normal control group, but the difference wasn't significant ( P >0.05). Conclusion The concentration of β EP in plasma in patients with VP decreased significantly,its mechanism might be relate to the decline of dopamine system's function induced by MCI of basal ganglion,lipid hyperoxidation and radical lesions in chronic cerebrovascular di sease,abnormality of immune function,decrease of stress and inflammation reaction. The significance of this study lay in evaluating severity,monitoring progression,estimating pro gnosis and guiding therapy effectively.

关 键 词：血管 帕金森综合征 放射免疫 Β-内啡肽 

分 类 号：R742.5[医药卫生—神经病学与精神病学]