髓鞘碱蛋白对脑梗死和多发性硬化的诊断价值  

Diagnostic value of the myelin basic protein in cerebral infarction and multiple sclerosis

作　　者：林菊香[1] 恽文伟[1] 李普蕾[1] 邓民斌[1] 

机构地区：[1]常州市第二人民医院,213003

出　　处：《临床神经病学杂志》2000年第4期224-226,共3页Journal of Clinical Neurology

摘　　要：目的　探讨髓鞘碱蛋白 (MBP)对脑梗死 (CI)和多发性硬化 (MS)的诊断价值。方法　对 114例CI患者、2 8例 MS患者、2 4名正常者血清以及部分患者脑脊液 (CSF)的 MBP进行了检测。结果　 CI、MS患者血清和 CSF的 MBP均显著高于正常对照组 (P<0 .0 1) ,MS组又高于 CI组 (P<0 .0 1) ;MS组中病情活动期患者 MBP又高于缓解期。结论　血清和 CSF的 MBP检测对 MS和 CI的鉴别诊断 ,以及判断 MS病情活动与否有一定价值。 MBP检测是一项比较特异、敏感可行的监控指标。Objective To investigate the diagnostic value of the myelin basic protein (MBP) in cerebral infarction (CI) and multiple sclerosis (MS).Methods The Serum and CSF MBP level in 114 patients with CI,28 patients with MS and 24 cases healthy persons were determined.Results MBP level in serum and CSF of the CI and MS patients were higher significantly than the normal control group( P <0.01). MS group was higher significantly than CI group( P <0.01); MBP level of the patients during active stage was higher than the remission stage in MS group. Conclusion Detection on MBP level of serum and CSF in diagnosis and judgement patients condition activities of MS and differential diagnosis of MS and CI had certain value.The method was a more special and sensitivity one,and could be used as monitoring index.

关 键 词：髓鞘碱蛋白 脑梗死 多发性硬化 诊断 

分 类 号：R743.3[医药卫生—神经病学与精神病学]