齐拉西酮对偏执型精神分裂症患者视觉持续注意和选择注意功能的影响  

Effects of ziprasidone on visual sustained attention and selective attention in paranoid schizophrenia

作　　者：陈旭[1] 唐茂芹[1] 由炜[1] 刘兆玺[1] 

机构地区：[1]山东省精神卫生中心,山东济南250014

出　　处：《中国新药与临床杂志》2013年第3期195-199,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：山东省医药卫生科技发展计划面上项目(2009年第HW057);山东省精神卫生中心院级重点课题

摘　　要：目的探讨偏执型精神分裂症患者视觉持续注意和选择注意功能状况及齐拉西酮对其的影响。方法81例偏执型精神分裂症患者设为研究组，按照同龄、相同性别及文化程度的配对原则选取81名健康志愿者作为对照组。研究组进行为期8wk的齐拉西酮（80～160mg·d-1）治疗，应用阳性和阴性症状量表（PANSS）评估疗效。同时，在治疗前后应用持续操作测试（CPT）和色词测试（CWT）评估两组视觉持续注意和选择注意功能并进行比较、分析。观察所发生的不良反应。结果治疗前，研究组CPT中认错数及遗漏数均高于对照组；CWT中完成数低于对照组，错误数和每正确反应平均耗时则高于对照组（P〈0．05或P〈0．01）。治疗后，研究组CPT中3位数认错数和CWT中错误数、每正确反应平均耗时均大于对照组（P〈0．05）。研究组CPT认错数及3位数遗漏数均较治疗前减少；CWT中完成数较治疗前增多，错误数、每正确反应平均耗时均较治疗前减少（P〈0．05或P〈0．01）。研究组治疗8wk末时PANSS各项评分均较治疗前显著降低（P〈0．05或P〈0．01），最常见的3种不良反应为胃肠道反应（16％）、锥体外系症状（11％）和窦性心动过速（9％）。结论偏执型精神分裂症患者存在持续注意和选择注意功能缺陷，短期内应用齐拉西酮治疗后功能有一定改善。AIM To explore the sustained attention and selective attention functions through visual pathway in patients with paranoid schizophrenia and the effects of ziprasidone. METHODS According to the same age, gender and educational background, 81 patients with paranoid schizophrenia paired with 81 normal people were assigned to study group and control group respectively. The study group was treated with ziprasidone 80 - 160 rag. d-1 for 8 weeks and its efficacy was assessed by Positive and Negative Syndrome Scale （PANSS） . In the two groups, the functions of visual sustained attention and selective attention were evaluated and analyzed by Continuous Performance Test （CPT） and Color Word Test （CWT） at baseline and end of the treatment. And the adverse reactions were recorded at any time. RESULTS Before the treatment, the mistaken and missed scores of CPT and error numbers and time per correct answer of CWT in the study group were higher than those of the control group （P 〈 0.05 or P 〈 0.01）, while completed numbers of CWT were lower （P 〈 0.05）. After the 8 week treatment, three- figure mistaken scores of CPT and error numbers and time per correct answer of CWT in the study group were remarkably higher than those of the control group （P 〈 0.05）. Compared with its baseline, the mistaken and three-figure missed scores of CPT and error numbers and time per correct answer of CWT reduced significantly （P 〈 0.05 or P 〈 0.01） , while completed numbers increased （P 〈 0.05）. The PANSS scores of the study group decreased significantly compared with those of the control group at the end of the treatment. （P 〈 0.05 or P 〈 0.01 ） . The most common adverse reactions were gastrointestinal tract response （16%）, extrapyramidal symptoms （11%）, and nodal tachycardia （9%）. CONCLUSION There are functional deficits of visual sustained attention and selective attention in patients with paranoid schizophrenia, and the function deficits can be improved by treatment of ziprasidone.

关 键 词：精神分裂症 偏执型 持续注意 选择注意 齐拉西酮 

分 类 号：R749[医药卫生—神经病学与精神病学]