转录因子FOXO4与胃癌及Hp感染关系的临床研究  

Clinical study of transcription factor FOXO4 in gastric cancer and its relationship with H.pylori infection

作　　者：张超[1] 王德荣[2] 曲飞[3] 孙少川[4] 

机构地区：[1]山东大学医学院,山东济南250012 [2]济南市中心医院消化内科,山东济南250013 [3]济南市中心医院病理科,山东济南250013 [4]济南市中心医院普外科,山东济南250013

出　　处：《中国现代普通外科进展》2013年第3期210-213,共4页Chinese Journal of Current Advances in General Surgery

摘　　要：目的:探讨FOXO4在胃癌发生过程中的表达、临床意义及其与幽门螺杆菌(Hp)感染的关系。方法:应用免疫组织化学SP法分别检测16例正常胃黏膜、26例慢性萎缩性胃炎伴肠上皮化生、36例异型增生胃黏膜及60例胃腺癌组织中FOXO4的表达,并检测患者Hp感染状况。结果:FOXO4在正常胃黏膜、慢性萎缩性胃炎伴肠上皮化生、异型增生胃黏膜及胃腺癌组织中的阳性率分别为100%、84.6%、69.4%和40.0%,胃腺癌组阳性率显著低于正常对照组(P<0.01)。FOXO4的阳性率在高、中分化和低分化型胃腺癌组织中呈现递减趋势,且其表达和淋巴结转移密切相关(P<0.05)。慢性萎缩性胃炎伴肠上皮化生及胃腺癌组织中FOXO4表达与Hp感染之间均无明显相关性(P均>0.05)。癌前病变组织中FOXO4表达与Hp感染率之间呈明显正相关(P<0.01)。结论:在胃黏膜癌变过程中,FOXO4的表达和作用逐渐下调;在癌前病变组织中FOXO4表达和Hp感染密切相关。Objective： To investigate the expressions and the clinical significance of FOXO4 in human carcinogenesis of gastric mucosa and its relationship with Helicobacter pylori （Hp） infection.Methods： The expressions of FOXO4 were detected by immunohistochemistry assay in human tissues, including 16 cases of normal gastric mucosa, 26 cases of intestinal metaplasia, 36 cases of atypical hyperplasia and 60 cases of gastric adenocarcinoma. H. pylori infection was evaluated by Rapid Urease Test and Hp special histological staining. Results： The positive rates of FOXO4 in patients with normal gastric mucosa, intestinal metaplasia, atypical hyperplasia and gastric adenocarcinoma were 100%,84.6%,69.4%and 40.0% respectively. FOXO4 expression in gastric adenocarcinoma tissue were significantly lower than those in the normal gastric mucosa （P〈0.01）. The positive rate of FOXO4 in gastric adenocarcinoma tissue was parallel with the decreasing in grade of differentiation. Its expression was correlated with lymph node metastasis （P〈0.05）. There were no significant correlation between the expression of FOXO4 and Hp infection rates in intestinal metaplasia and gastric adenocarcinoma lesions （P〉0.05）. There was a positive relation between the expression of FOXO4 and Hp infection rates in precancerous lesions （P〈0.01）. Conclusion： The expression of FOXO4 progressively down-regulates during the course of gastric adenocarcinoma progression. There is a correlation between the expression of FOXO4 and Hp infection positive rates in precancerous lesions.

关 键 词：胃肿瘤 转录因子 FOXO4 幽门螺杆菌 

分 类 号：R737.9[医药卫生—肿瘤]