可完全切除的非小细胞肺癌患者ERCC1和RRM1表达与预后的关系  

Significance of the expressions of ERCCi and RRMi in completely resected non-small cell lung cancer

作　　者：王伟[1] 宋伟安[1] 路平[2] 李军[1] 胡艳正[1] 尚立群[1] 李学昌[1] 文锋[1] 刘军强[1] 

机构地区：[1]海军总医院胸外科,北京100048 [2]海军总医院病理科,北京100048

出　　处：《中华胸心血管外科杂志》2013年第3期156-160,共5页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：目的探讨非小细胞肺癌完全切除术后ERCC1、RRM1的表达与预后的关系。方法86例NSCLC手术后标本中肿瘤组织应用免疫组织化学方法进行ERCC1、RRM1蛋白表达检测。回顾性分析NSCLC患者的临床特征、生存期与肿瘤组织中ERCC1、RRMI蛋白表达的关系。结果86例手术根治性切除NSCLC组织中ERCC1、RRM1蛋白表达阳性率分别为41．9％、36．1％。ERCC1和RRM1蛋白表达阳性率与患者的性别、年龄、吸烟状况、淋巴结转移情况、组织学类型及临床分期均无明显相关性（P〉0．05）。ERCC1蛋白表达阳性患者的无疾病进展时间（28．5个月）和1、2年生存率（94．3％、62．6％）与阴性患者（30．0个月，94．3％、71．4％）差异均无统计学意义（P〉0．05）。RRM1蛋白表达阳性患者的无疾病进展时间（25．0个月）和1、2年生存率（86．6％、55．8％）低于RRM1蛋白表达阴性患者（31．2个月，98．2％、65．1％），差异有统计学意义（P〈0．05）。结论可完全切除NSCLC的患者预后与肿瘤组织中RRM1蛋白表达相关。Objective To explore the relationship between the expression of ERCC1, RRM1 and the clinical prognosis in operable non-small cell lung cancer （NSCLC） patients. Methods The expression of ERCC1 and RRM1 protein in 86 cases was detected by immunohistoehemical methods. The relationship between the expression of ERCC1 and RRM1 protein and the clinical characteristics, postoperative survival were analyzed retrospectively. Results The positive expression of ERCC1, RRM1 protein in 86 cases was 47.5% , 35.2% , respectively. There was no significant correlation between the positive expres- sion of ERCC1 and RRM1 protein and gender, age, smoking status,lymph node metastasis, histological types and clinical stag- ing （P 〉 0.05 ）. There was no significant difference in progressive free survival （PFS） and 1-, 2-year survival rate between ERCClpositive group （28.5 months,94.3 % , 62.6% ） and ERCC1 negative group （30.0 months, 94.3% , 71.4% ） , P 〉 0.05. Patients with positive expression of RRM1 protein had a lower PFS and 1-, 2-year survival rate （25.0 months, 86.6% , 55.8% ）than those with negative expression of RRM1 protein （31.2 months, 98.2% , 65.1% ）, P 〈0.05. Conclusion The expression of RRM1 protein in cancer tissues is closely related to the clinical prognostic and survival status in operable NSCLC patients.

关 键 词：癌 非小细胞肺 ERCC1 RRM1 预后 无病生存 无疾病进展时间 

分 类 号：R734.2[医药卫生—肿瘤]