小剂量奥氮平实体瘤化疗止吐的临床观察  

Antiemetic effect of low dose olanzapine in solid tumor chemotherapy

作　　者：吕雅蕾[1] 刘巍[1] 杜玉娟[1] 冯莉[1] 王玉栋[1] 王龙[1] 

机构地区：[1]河北医科大学第四医院肿瘤内科,河北石家庄050011

出　　处：《中华肿瘤防治杂志》2013年第7期544-545,554,共3页Chinese Journal of Cancer Prevention and Treatment

摘　　要：目的:探讨小剂量奥氮平在实体瘤化疗止吐中的应用价值。方法:按照动态随机对照原则,将60例2011-08-02-2012-07-31在河北医科大学第四医院肿瘤内科住院的实体瘤化疗的患者动态随机分为干预组和对照组,每组30例。干预组在常规化疗同时,给予常规止吐药物及口服小剂量奥氮平(奥氮平2.5mg,早、晚各1次口服;或5mg,每晚口服1次),对照组仅给予常规止吐药物治疗。观察恶心呕吐的发生率和其他不良反应发生率。结果:干预组完全缓解22例(73.3%),部分缓解5例(16.7%),轻度缓解2例(6.6%),无效1例(3.3%),有效率为90.0%;对照组,完全缓解11例(36.7%),部分缓解14例(46.7%),轻度缓解4例(13.3%),无效1例(3.3%),有效率为(83.3%)。两组疗效差异有统计学意义,χ2=8.596,P=0.035。患者的化疗依从性干预组明显优于对照组,便秘等其他不良反应两组差异无统计学意义,P>0.05。结论:常规止吐治疗联合小剂量奥氮平在实体瘤化疗中,可以明显减轻患者化疗相关恶心呕吐的发生率,不良反应耐受性好,提高患者的化疗依从性。OBJECTIVE： To investigate the vomit-stopping value of low dose olanzapine in chemotherapy. METHODS： Based on randmized,controlled and matched principles, 60 cases with solid malignant tumors who were treated with chemotherapy from 08-02-2011 to 07-31-2012 hospitalized in Oncology Department, fourth Hospital of Hebei Medical University were randomly divided into interventional and control groups, and each group with 30 cases. Low dose olanzapine （olanzapine 2.5 mg orally twice per day or 5 rag orally once per night） were add to conventional antiemetic in intervention group, while only routine antiemetic was used in control group. The incidences of nausea,vomitin and other adverse events were observed. RESULTS： There were 22 cases CR（73.3%） ,5 cases PR（16.7%） ,2 cases mild remission（6.6%） ,1 case ineffectivness（3.3M） and the effective rate was 90.0% in intervention group, while that was 11 CR （36.7 % ）, 14 PR（46.7 % ）, 4 mild remission （ 13.3 % ）, 1 ineffectivness （3.3 %） and the effective rate was 83.3 % in control group. Differences between the two groups was statistically significant （3（2 = 8. 596, P= 0. 035）. The chemotherapy compliance of patients in intervention group was significantly better than that in control group. There was no significant difference in other adverse effects （P〉0. 05）. CONCLUSION： Routine antiemetic therapy in combination with low dose olanzapine in solid tumors chemotherapy can significantly reduce the incidence of chemotherapy-related nausea and vomiting, and their adverse reactions is well tolerated.

关 键 词：肿瘤 药物疗 恶心 预防和控制 呕吐 预防和控制 

分 类 号：R730.53[医药卫生—肿瘤]