蛋白质中四类简单超二级结构的分类  

The Classification of 4-Class simple Supersecondary Structures in Proteins

作　　者：高苏娟[1] 胡秀珍[1] 

机构地区：[1]内蒙古工业大学理学院,呼和浩特010051

出　　处：《内蒙古工业大学学报（自然科学版）》2013年第1期21-26,共6页Journal of Inner Mongolia University of Technology：Natural Science Edition

基　　金：国家自然科学基金资助项目(30960090);国家自然科学基金项目(31260203)

摘　　要：蛋白质超二级结构预测是三级结构预测的一个非常重要的中间步骤。本文从蛋白质的一级序列出发,运用了一种改进的预测算法:以氨基酸组分和紧邻氨基酸分别作为参数,输入离散增量算法的单分类器中,通过加权融合单分类器的计算结果,对四类超二级结构进行了预测,取得了较好的预测结果。四类超二级结构的平均预测总精度达到78.3%,Matthew's相关系数在0.65以上。The protein supersecondary structure prediction is an important step to search protein tertiary structure.According to the primary structure of proteins,an improved method for predicting 4-class protein supersecondary structures is used.Based on the increment of diversity algorithm,a set of classifieries is built by different characteristic parameters,such as amino acids and twin amino acids.Then the outcomes of various classifieries are fused with weighted factors,and a better result is obtained.The average prediction accuracy of 4-class supersecondary structures was 78.3%,Matthew＇s correlation coefficient was over 0.65.

关 键 词：离散量 离散增量 蛋白质超二级结构 

分 类 号：Q61[生物学—生物物理学]