tPSA和cPSA联合检测在前列腺癌诊断中的作用  

Impact of combined testing of tPSA and cPSA in prostatic cancer diagnosis

作　　者：祝存海[1] 叶昶[1] 王进恩[1] 宋勇波[1] 刘小兵[1] 

机构地区：[1]湖北省孝感市中心医院泌尿外科,湖北孝感432100

出　　处：《海南医学院学报》2013年第3期390-392,共3页Journal of Hainan Medical University

基　　金：中国高校医学期刊临床专项资金项目(112210564)~~

摘　　要：目的:探讨总前列腺特异抗原(tPSA)和复合前列腺特异抗原(cPSA)联合检测在前列腺癌诊断中的作用。方法:选取我院收治的经临床及病理组织活检证实的前列腺癌(PCa)患者46例,前列腺增生(BPH)患者214例,采用化学发光法对两组患者血清tPSA和cPSA进行检测分析,评价联合检测tPSA和cPSA在前列腺癌诊断中的价值。结果:PCa组cPSA、tPSA阳性率显著高于BPH组(P<0.05),PCa组与BPH组之间的tPSA、cPSA值及cPSA/tPSA比值均存在着显著性差异(P<0.05);利用cPSA与cPSA/tPSA在诊断灰值区附近可以有效地区分BPH和PCa患者,联合使用cPSA、tPSA和cPSA/tPSA比值进行筛选诊断时,其临床诊断概率比单纯使用tPSA、cPSA或cPSA/tPSA比值更高。结论:前列腺癌诊断中联合检测tPSA和cPSA可以提高前列腺癌的诊断特异性,在诊断灰区内也具有很重要的临床意义。Objective： To discuss the impact of combined testing of tPSA and cPSA in diagnosing prostatic cancer （PCa）. Methods： A total of 46 PCa patients and 214 benign prostate hyperplasia （BPH） patients admitted in our hospital and clinically confirmed by pathological biopsy were enrolled, tPSA and cPSA in both groups were measured using chemiluminescent assay so as to evaluate the vale of combined testing of tPSA and cPSA in diagnosing PCa. Results： PCa group had significantly higher positive rates of tPSA and cPSA than BPH group （P〈0.05）, and statistical differences were observed between two groups in tPSA, cPSA values and cPSA/tPSA ratio （P〈0.05）. BPH and PCa patients could be distinguished efficiently in diagnostic grey zone with the help of cPSA value and ePSA/tPSA ratio. Combined application of tPSA, cPSA values and cPSA/tPSA ratio provided higher clinical diagnostic rate than tPSA, cPSA values or cPSA/tPSA alone. Conclusions： Combined testing of tPSA and cPSA can raise specificity in diagnosing prostatic cancer. It is with great clinical significance in diagnosis grey zone as well.

关 键 词：总前列腺特异抗原(tPSA) 复合前列腺特异抗原(cPSA) cPSA TPSA 前列腺癌 特异性 

分 类 号：R737.25[医药卫生—肿瘤]