HMGB1在多种人体恶性肿瘤组织、癌旁组织中的表达及意义  

Expression of HMGB1 in malignant tumor tissues and adjacent normal tissues and its significance

作　　者：肖建彪[1] 陈龙华[1] 陈斌[2] 

机构地区：[1]南方医科大学南方医院,广州510515 [2]广州军区广州总医院

出　　处：《山东医药》2013年第12期1-3,I0001,共4页Shandong Medical Journal

基　　金：国家自然科学基金资助项目(81101822);广东省自然科学基金资助项目(10451001002005047);广州市科技计划重点项目(11C26090521)

摘　　要：目的检测高迁移率蛋白B1(HMGB1)在人体常见恶性肿瘤组织、癌旁组织中的分布和表达,并探讨其意义。方法 48例癌组织和48例癌旁组织组成96点的组织芯片,应用免疫组织化学方法检测HMGB1在癌组织和癌旁组织中的表达情况。结果 HMGB1在恶性肿瘤组织中阳性率为89.6%、正常组织阳性率为77.1%、癌组织强阳性率为54.1%、癌旁正常组织强阳性率为6.5%,恶性肿瘤组织与癌旁正常组织中HMGB1表达差异具有统计学意义(P<0.01)。结论 HMGB1在多种恶性肿瘤组织中呈强阳性表达,其可能是鉴别正常组织与癌组织潜在的生物学标志物。Objective To study the distribution and expression of HMGB1 in human malignant tumor tissues and ad- jacent normal tissues. Methods Samples of malignant tumor tissues and adjacent normal tissues were collected from 48 patients with multi-system for construction of tissue microarray. The expression of HMGB1 was detected by immunohisto- chemistry. Results HMGB1 was detected in 89.6% of malignant tumor tissues, while it was detected in 77.1% of adja- cent normal tissues. Stronge positive was detected 54.1% in malignant tumor tissues, while it was detected 6.5% in adja- cent normal tissues. HMGB1 expression had significant difference between malignant tumor tissues and adjacent normal tis- sues （P 〈0.01 ）. Conclusion HMGB1 overexpression in malignant neoplasms could be a novel, effective and supple- mentarv biomarker for tumors.

关 键 词：肿瘤组织 组织芯片 高迁移率蛋白B1 免疫组织化学 

分 类 号：R730.43[医药卫生—肿瘤]