Morinda citrifolia L. (noni) and memantine attenuate periventricular tissue injury of the fourth ventricle in hydrocephalic rabbits  

作　　者：Sibel Kktürk Süreyya Ceylan Volkan Etus Nezih Yasa Savas Ceylan 

机构地区：[1]Department of Histology and Embriyology,Faculty of Medicine,Ordu University,Ordu,Turkey [2]Department of Histology and Embriyology,Faculty of Medicine,Kocaeli University,Kocaeli,Turkey [3]Department of Neurosurgery,Faculty of Medicine,Kocaeli University,Kocaeli,Turkey

出　　处：《Neural Regeneration Research》2013年第9期773-782,共10页中国神经再生研究（英文版）

基　　金：sponsored by a grant from the Education and Research Foundation of Faculty of Medicine,Kocaeli University,No.2009/45

摘　　要：This study was designed to evaluate the neuroprotective effects of Morinda citrifofia L. （Rubiaceae） commonly known as noni, and memantine （a N-methy-D-aspartate receptor inhibitor） on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine （20 mg/kg, intraperitoneally; memantine-treated group） or noni （5 mL/kg, intragastrically; noni-treated group） was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle.This study was designed to evaluate the neuroprotective effects of Morinda citrifofia L. （Rubiaceae） commonly known as noni, and memantine （a N-methy-D-aspartate receptor inhibitor） on hydrocephalus-induced neurodegenerative disorders. Kaolin was injected into the cistern magna of male adult New Zealand rabbits to establish a hydrocephalus animal model. Memantine （20 mg/kg, intraperitoneally; memantine-treated group） or noni （5 mL/kg, intragastrically; noni-treated group） was administered daily for 2 weeks. Microtubule-associated protein-2 and caspase-3 immunohistochemistry were performed to detect neuronal degeneration and apoptosis in the periventricular tissue of the fourth ventricle of rabbits. Microtubule-associated protein-2 staining density was significantly decreased in the hydrocephalic group, while the staining density was significantly increased in the memantine- and noni-treated groups, especially in the noni-treated group. Noni treatment decreased the number of caspase-3-positive cells in rabbits with hydrocephalus, while memantine had no effect. These findings suggest that noni exhibits more obvious inhibitory effects on hydrocephalus-induced neurodegenerative disorders than memantine in periventricular tissue of the fourth ventricle.

关 键 词：neural regeneration neurodegenerative disease traditional Chinese medicine hydrocephalusMorinda citrifolia L. （noni） MEMANTINE fourth ventricle periventricular tissue microtubule-associated protein-2 caspase-3 apoptosis grants-supported paper photographs-containing paper neuroregeneration 

分 类 号：R285.5[医药卫生—中药学]