喉鳞癌CgA、Syn表达的临床分析  

The clinical study of the expression of the CgA and Syn in laryngeal squamous carcinoma

作　　者：侯丽[1] 刘静[1] 刘怀涛[1] 马瑞霞[1] 高建中[1] 

机构地区：[1]宁夏医科大学总医院耳鼻咽喉头颈外科,宁夏银川750004

出　　处：《宁夏医学杂志》2013年第3期214-215,I0001,共3页Ningxia Medical Journal

摘　　要：目的研究嗜铬蛋白A(CgA)和突触蛋白(Syn)在喉鳞癌组织中的表达,分析CgA、Syn在喉部鳞癌中表达的临床意义。方法将2000—2006年保存完好的77例喉鳞癌石蜡标本进行切片,应用免疫组化Elivision法检测CgA和Syn在喉鳞癌中的表达,分析其表达与临床特点间的关系。结果本实验研究证实喉鳞癌组织中存在不同程度的神经内分泌分化倾向,CgA和Syn均在细胞浆出现阳性着色,总体的阳性率16.8%;神经内分泌分化与喉癌的临床分期有相关性,Ⅰ和Ⅱ期的阳性率为6.8%,明显低于Ⅲ期和Ⅳ期(23.6%和38.1%,P<0.05);神经内分泌分化在不同部位喉癌组织阳性表达率声门上型为22.2%、声门型为12.5%、声门下型为50%(P>0.05);神经内分泌分化在高分化的阳性率31.82%,略高于中低分化的15.0%和22.86%(P>0.05)。结论喉鳞状细胞癌中存在不同程度的神经内分泌分化表达;喉癌的神经内分泌分化与发病部位无相关,与喉鳞癌分化程度相关,分化低与分化程度高有一定的差异;与临床分期有显著相关性,即分期越晚阳性率越高,为喉癌的基础研究以及影响预后相关因素的研究提供了新的思路。Objective To study the expression of chromgranin A （CgA） and synaptophysin （Syn） in laryngeal squamous carci- noma and analyze their clinical significance. Methods The expressions of CgA and Syn in laryngeal squamous carcinoma tissues were detected by immunohistochemical method, and analyzed the relationship between their expression and clinical features. Results In 77 cases with laryngeal squamous carcinoma, 18 cases （23.4%） had positive neuroendocrine differentiation. Laryngeal carcinoma with neuroendocrine differentiation had no relationship with histological grading and the site of tumor （ P 〉 0.05 ）. The ratio of laryngeal squa- mous carcinoma with neuroendocrine differentiation in the cases of II[ stage and 1V stage （29.63%, 38.10% ） was higher than the ratio of I and U stage （6.8%） （ P 〈 0.05 ）. Conclusion Laryngeal squamous carcinoma with neuroendocrine differentiation has relation- ship with the clinical stage, but no relationship with the site of tumor, histological grading and so on. It would provide new ideas to the basic study of laryngeal cancer.

关 键 词：喉鳞状细胞癌 神经内分泌分化 免疫组织化学 CgA SYN 

分 类 号：R739.65[医药卫生—肿瘤]