小胶质细胞表面受体在神经病理性疼痛中的作用研究进展  

Research Advances in the Role of Microglia′s Surface Receptors in Neuropathic Pain

作　　者：底妍[1,2] 李伟彦[2] 

机构地区：[1]南京大学医学院临床医学院,南京210002 [2]南京军区南京总医院麻醉科,南京210002

出　　处：《医学综述》2013年第6期1108-1111,共4页Medical Recapitulate

摘　　要：神经病理性疼痛(NP)是一种顽固性的慢性疼痛综合征,对患者的身心健康有着极大的影响。小胶质细胞是神经元-胶质细胞网络中最为活跃的分子,其细胞膜上存在着许多离子通道和神经递质受体,通过复杂的信号转导通路产生和释放神经活性物质参与疼痛信号的转导与调控,在慢性疼痛的产生过程中起着重要作用。总结分析小胶质细胞表面受体在NP中的作用研究进展,对于促进该领域的基础研究和临床诊疗均有重要意义。Neuropathic pain is an intractable chronic pain syndrome with a great impact on the patient′s physical and psychological health.Microglia is the most active member of the neuron-glial cells network,with many ion channels,neurotransmitter receptors on their cell membranes and has a complex signal transduction pathway to produce and release neural active substances involved in pain signal transduction and regulation so that it plays a pivotal role in the development of chronic pain.Here is to analyze the role of microglia′s surface receptors in neuropathic pain which has a great significance for the promotion of the basic research and clinical diagnosis and treatment.

关 键 词：神经病理性疼痛 小胶质细胞 神经递质 受体 前致炎因子 

分 类 号：R74[医药卫生—神经病学与精神病学]