子宫内膜癌中抑癌基因P27蛋白与癌基因P185蛋白的表达及临床意义  被引量:2

Protein expression and clinical significance of tumor suppressor gene P27 and oncogene P185 in endometrial carcinoma

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作  者:钱沁佳[1] 

机构地区:[1]海南省第三人民医院妇产科,海南三亚570000

出  处:《重庆医学》2013年第10期1132-1133,共2页Chongqing medicine

摘  要:目的探讨抑癌基因P27蛋白与癌基因P185蛋白联合标记在子宫内膜癌早期诊断中的价值。方法采用S-P免疫组化方法对2008年1月至2010年3月间该院收治的子宫内膜癌患者66例(癌症组),子宫非典型增生病变患者29例(增生组),并设立子宫内膜正常组织31例为对照组织进行检测。结果癌症组P27表达阳性率最低,组间比较差异有统计学意义(P<0.05);而对照组与增生组比较,差异无统计学意义(P>0.05)。癌症组P185的表达与增生组比较,差异有统计学意义(P<0.05);对照组与癌症组及增生组比较,差异显著有统计学意义(P<0.01)。结论该研究表明子宫内膜癌中P185蛋白与P27蛋白表达表达呈负相关,P27蛋白与P185蛋白对肿瘤的发生和调控有重要作用,临床联合检测,对子宫内膜癌的诊断有积极意义。Objective To discuss the value of combined mark of tumor suppressor gene P27 and oncogene P185 in the early diagnosis of endometrial carcinoma.Methods A total of 66 patients with endometrial carcinoma(carcinoma group) and 29 cases of endometrial atypical hyperplasia(hyperplasia group) admitted to our hospital from January 2008 to March 2010,together with 31 patients with normal endometrium(control group) were selected and received S-P immunohistochemistry testing.Results P27 expression has the lowest positive rate in carcinoma group.The differences between groups were statistically significant(P0.05),while there was no statistical difference between control group and hyperplasia group(P0.05).There is significant difference of P185 expression between carcinoma group and hyperplasia group(P0.05).There were significant difference among control group,carcinoma group and hyperplasia group(P0.01).Conclusion This study shows that the expression of P27 and P185 protein in endometrial carcinoma has negative correlation.P27 and P185 protein plays an important role in the occurrence and regulation of tumor.Clinical combined testing has positive significance in the early diagnosis,treatment and prognosis of tumor.

关 键 词:子宫内膜肿瘤 P27 P185 早期诊断 S-P免疫组化 

分 类 号:R737.33[医药卫生—肿瘤]

 

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