儿童急性淋巴细胞白血病染色体异常与预后关系研究  

Relationship between Chromosomal Abnormalities and Prognosis in Children with Acute Lymphoblastic Leukemia

作　　者：赖长城[1] 梁昌达[1] 李艳红[1] 何飞[1] 

机构地区：[1]江西省儿童医院血液科,南昌330006

出　　处：《南昌大学学报（医学版）》2013年第1期56-59,共4页Journal of Nanchang University：Medical Sciences

摘　　要：目的研究ALL患儿染色体异常核型与疗效及预后的关系。方法对155例ALL患儿的骨髓/外周血细胞进行染色体核型分析,观察临床疗效。结果 1)155例ALL患者中,正常核型63例(40.65%),异常核型92例(59.35%),其中结构异常48例(52.17%),数目异常者39例(42.39%)。2)t(9;22)易位的发生率为3.87%,它是预后不良的标志。3)t(12;21)易位染色体异常占18.71%,其预后良好。4)高二倍体核型是预后良好的标志,而具有其他数目和结构异常核型的白血病,则预后不良。结论 ALL患者染色体核型异常发生频率较高,染色体核型分析对ALL的指导治疗及预后判断具有重要作用。Objective efficacy and prognosis in To investigate the relationship of chromosomal abnormalities to curative children with acute lymphoblastic leukemia （ALL）. Methods The chromosome karyotype was assessed in bone marrow or peripheral blood cells from 155 ALL patients and the curative effect was observed. Results Among the 155 ALL patients,63 （40.65%） had normal karyotype,92 （59.35%） had abnormal karyotype,48 （52.17%） had structural chromosomal abnormalities, and 39 （42. 39%） had numerical chromosomal aberrations. In addition, 6 children （3.87%） had t（9 ;22） translocation （a marker of poor prognosis）. Twenty-nine children （18.71%） had t（12;21） translocation （a marker of good prognosis）, which was the most common chromosomal abnormality in ALL childhood. Hyperdiploid karyotype was a favorable prognostic indicator, but other numerical and structural abnormalities were markers of poor prognosis. Conelusion Children with ALL have a higher frequency of chromosome abnormalities. Karyotype analysis plays an important role in guiding treatment and prognosis of ALL.

关 键 词：急性淋巴细胞白血病 儿童 染色体 预后 

分 类 号：R733.7[医药卫生—肿瘤]