含1,2,4-三唑硫醚单元的新型喹唑啉酮类衍生物的合成及其抗菌活性  

Synthesis and Fungicidal Activities of Novel Quinazolinone Derivatives Containing 1,2,4-Triazolyl-thioether Unit

作　　者：鲍小平[1] 刘军虎[1] 张峰[1] 邹林波[1] 蹇军友[1] 

机构地区：[1]贵州大学精细化工研究开发中心教育部绿色农药与农业生物工程重点实验室,贵州贵阳550025

出　　处：《合成化学》2013年第2期200-203,共4页Chinese Journal of Synthetic Chemistry

基　　金：贵州省农业科技攻关资助项目(20093010)

摘　　要：采用活性单元拼接法设计并合成了10个含1,2,4-三唑硫醚单元的新型喹唑啉酮类衍生物(1a～1j),其结构经1H NMR,IR,MS和元素分析表征。初步生物活性测试结果表明,部分化合物具有一定的抗菌活性。其中1a对小麦赤霉菌的抑制率为40%;1j对半夏立枯菌的抑制率为34%;1e,1f和1h对水稻纹枯菌的抑制率分别为35%,34%和34%。Ten novel quinazolinone derivatives 2 -methyl-3 - [ （ 3-thioether-5-methyl- 1,2,4-triazol- 4-yl） ] quinazolin-4（3H）-one（ 1a -1j） were designed and synthesized by coupling method of active fragments. The structures were characterized by 1H NMR, IR, MS and elemental analysis. The pre- liminary bioassay showed that some target compounds had certain fungicidal activities, especially, la showed 40% inhibitory activity aganist Gibberella zeae; lj possessed 34% inhibitory activity aganist Rhizoctonia solani; le, If and lh dispayed 35% , 34% and 34% inhibitory activity aganist Pellicu- laria sasakii, respectively.

关 键 词：1 2 4-三唑硫醚 喹唑啉酮 合成 抗菌活性 

分 类 号：O626.26[理学—有机化学] O626.32[理学—化学]