血清PRL水平与MRI扫描垂体催乳素瘤的对比分析及临床应用  

Comparative Analysis and Clinical Application of Serum PRL and MRI Scan on Pituitary Prolactinoma

作　　者：朱梅[1] 张勇[2] 彭虹[2] 邱红[3] 袁鹏[3] 阮书平[1] 

机构地区：[1]湖北医药学院附属东风医院核医学科,442008 [2]湖北医药学院附属东风医院影像科,442008 [3]湖北医药学院附属东风医院检验科,442008

出　　处：《放射免疫学杂志》2013年第2期135-137,共3页Journal of Radioimmanology

摘　　要：目的:通过血清催乳素(PRL)含量与MRI扫描垂体催乳素瘤的对照研究,观察垂体催乳素瘤的特征,可进一步评价垂体催乳素瘤的生物学行为。方法:搜集确诊垂体催乳素瘤患者66例,同时行垂体MRI常规序列扫描及同位增强扫描。结果:微腺瘤患者中女性多见;好发在垂体前叶后部两侧。大腺瘤患者中男性多见;性腺功能减低发生率高;侵袭性腺瘤发生率高、复发率高。催乳素瘤的大小与血清PRL水平呈直线相关性(r=0.4372,P<0.01)。结论:血清PRL增高,结合MRI动态增强扫描可准确显示垂体催乳素瘤的形态及位置,对照研究可初步评估肿瘤的生物学行为,为临床诊断治疗提供重要依据。Objective Through the serum prolactin level and MRI scan pituitary prolactinoma case-control study, observation of pi- tuitary prolactin-secreting tumor characteristics, further evaluation of pituitary prolactinoma biological behavior. Mothods To collect the undiagnosed pituitary prolactinoma patients 66 cases, at the same time of pituitary MR[ routine sequence scanning and parity enhanced scan. Results Microadenoma of most of the patients were females, occurred in the anterior pituitary of the two side of the back. Large adenomas in patients with male gonadal dysfunction; High incidence of invasive adenomas; high incidence rate, high recurrence rate. Prolactin-secreting tumor size and serum level of PRL showed a linear correlation （ r = 0.4372, P 〈 0.01 ）. Conclusion Serum PRL in- creased, combining with dynamic enhanced MR[ scan can accurately display the PRL of pituitary prolactinoma shape and position, case- control study preliminary assessment of tumor biological behavior, and provide important basis for clinical diagnosis and treatment.

关 键 词：催乳素 垂体肿瘤 磁共振成像 生物学 

分 类 号：R736.4[医药卫生—肿瘤]