高龄胃肠肿瘤患者术中腹腔区域性缓释化疗临床观察  

Clinical observation of abdominal regional slow-release chemotherapy in elderly patients with gastrointestinal neoplasm

作　　者：杜海鹏[1] 戚峰[1] 

机构地区：[1]天津医科大学总医院普通外科,天津300052

出　　处：《天津医科大学学报》2013年第2期121-123,共3页Journal of Tianjin Medical University

摘　　要：目的:观察高龄(>70岁)胃肠肿瘤患者术中腹腔区域性缓释化疗的安全性及使用效果。方法:将56例高龄肿瘤患者分为治疗组和对照组,两组常规行肿瘤根治术。治疗组术中在瘤床和沿淋巴引流途径多点植入氟尿嘧啶缓释剂600～800 mg,对照组仅行手术治疗。观察两组不良反应、安全性及疗效。结果:两组血常规及肠功能恢复时间无差异(P>0.05),治疗组不良反应发生率与对照组无明显差异(P>0.05)。两组均无死亡。治疗组近期转移、复发率低于对照组(P<0.05)。两组间的总体生存率及无病生存率差异有统计学意义(P<0.05)。结论:高龄肿瘤患者术中应用区域性缓释化疗安全可行,有一定治疗效果。Objective： To investigate the therapeutic effectiveness and safety of abdominal regional slow-release chemotherapy in elderly patients （〉70） with gastrointestinal neoplasm. Methods ： 56 patients with gastrointestinal cancer were divided into two groups on a volun- tary basis. Both of the two groups were performed radical operation .In treatment group sustained releasing-fluorouracil （600-800 mg） was also implanted to tumor cavity and lymph region during the operation. Side effects, safety and therapeutic effectiveness were observed. Results：The incidence of short-term local recurrence, in the treated group was lower than that in the control group, with significant sta- tistical difference （P〈0.05）. There was no significant statistical difference in the effects and postoperative complications between the two groups （P〉0.05）. Significant statistical difference of overall survival and disease-free survival was observed between the two groups （P〈 0.05）. Conclusion：The way of intraoperative implantation of sustained releasing-fluorouraeil in elderly patients with gastrointestinal neo- plasm is safe, and it might be a effective method to prevent short-term local recurrence.

关 键 词：高龄患者 胃肠肿瘤 氟尿嘧啶 缓释化疗 

分 类 号：R735[医药卫生—肿瘤]