残胃癌患者的生命质量评价  

Evaluation of life quality in patients with gastric remnant cancer

作　　者：尹曙明[1] 张赣生[1] 马海芬[1] 黄一沁[1] 陈洁[1] 保志军[1] 于晓峰[1] 

机构地区：[1]复旦大学附属华东医院消化科,上海200040

出　　处：《中华消化杂志》2013年第3期155-159,共5页Chinese Journal of Digestion

基　　金：上海市医学伦理学研究基金（医学伦理2011-013）;上海申康医院发展中心市级医院适宜技术推广和应用项目（SHDC12010213）

摘　　要：目的研究残胃癌患者的健康相关生命质量（HRQoL）及其影响因素。方法选取因早期胃癌接受胃大部切除术≥10年者130例，根据术后残胃是否发生癌变分为残胃癌组80例和残胃组50例。2组均接受癌症普适性量表生命质量测定量表（QLQ）-C30和胃癌特异性量表QLQ-ST022调查，评价其HRQoL。正态分布数据两组间比较行t检验。非正态分布数据两组间比较行Wilcoxon秩和检验。采用最优尺度回归分析筛选HRQoL相关的临床影响因素。结果所有研究对象均完成量表调查。与健康对照组比较，残胃癌组总体生命质量评价、躯体功能、角色功能、情绪功能、认知功能、社会功能评分皆较低，差异均有统计学意义（t=-6.678、-7.111、-10.605、-5.748、-4.765、-21.170，P均〈0.01），疲倦、疼痛、腹泻、恶心与呕吐、食欲不振、经济困难、吞咽困难、腹痛、反流症状、饮食受限、焦虑、身体外观、脱发评分皆较高，差异均有统计学意义（t=6.925、4.218、4.728，Z=-5.236、-7.890、-7.698、-10.058、-3.612、-6.914、-9.711、9.940、-7.987、-4.966，P均〈O.01）。与残胃组比较，残胃癌组总体生命质量评价、躯体功能、角色功能、情绪功能、认知功能、社会功能评分皆较低，差异均有统计学意义（t=-5.861、-5.821、-7.077、-7.999、-2.808、-5.710，P均〈0.01），疲倦、疼痛、恶心与呕吐、食欲不振、经济困难、吞咽困难、饮食受限、焦虑、身体外观、脱发评分皆较高，差异均有统计学意义（t=-9.363、6.842，Z=-2.654、-6.256、-3.266、-4.132、-2.854、-7.996、-4.258、-2.005，P均〈0.01）。与健康对照组比较，残胃组社会功能评分较低，差异有统计学意义（t=-9.820，P〈O.01），腹泻、恶心与呕吐、经济困难、吞咽困难、反流症状、饮食受限、身体外观、脱发评分皆较高，差异均有统计学意义（t=-3.020，Z=-1.981、-3.775、-6.505、-6.0Objective To investigate the health-related quality of life（HRQoL） and its influencing factors in patients with gastric remnant cancer （GRC）. Methods A total of 130 patients received gastrectomy more than 10 years ago because of early gastric cancer. According to the gastric remnant canceration after the surgery, patients were divided into GRC group （80 cases） and gastric remnant group （50 cases）. Both the patients of these two groups accepted questionnaires of cancer patients＇ quality of life questionnaire （QLQ）-C30 and gastric cancer specific questionnaire QLQ-STO22, the HRQoL were evaluated. The comparison between two groups with normal distribution of data was aralyzed by t test. Wileoxon rank sum test was applied for the comparison between two groups with non-normal distribution of data. Optimal scaling regression analysis was used for screening HRQoL related clinical influencing factors. Results All the research objectives finished the questionnaires survey. Compared with health control group, the scores of GRC group were lower, which included quality of life evaluation, physical function, role function, emotional function, cognitive function and social function, and the differences were statistically significant （t=-6.678,-7.111,-10.605,-5.748,-4.765 and -21.170, all P〈0.01）. The scores of fatigue, pain, diarrhea, nausea and vomiting, loss of appetite, economic difficulties, dysphagia, abdominal pain, reflux symptoms, diet restricted, anxiety, physical appearance and hair loss were higher, and the differences were significant （t=6.925, 4.218, 4.728 and Z=-5.236,-7.890,-7.698,-10.058,-3.612,-6.914,-9.711,9.940,-7.987 and -4.966, all P〈0.01）. Compared with gastric remnant group, the scores of GRC group were lower, which included quality of life evaluation, physical function, role function, emotional function, cognitive function and social function, and the differences were statistically significant （t=-5.861,-5.821,-7.077,-7.999,-2.808 and -5. 710, all P〈0.01）. Howeve

关 键 词：胃肿瘤 胃切除术 生活质量 问卷调查 

分 类 号：R735.2[医药卫生—肿瘤]