低分割放疗治疗老年非小细胞肺癌的临床观察  

Clinical observation of elderly non-small-cell lung cancer patients treated by hypofractionated high-dose radiotherapy

作　　者：李小龙[1] 党亚正[1] 卫伟[1] 陆婉玲[1] 赵宏亮[1] 陆宙[1] 胡飚 杨婷[1] 

机构地区：[1]解放军第323医院肿瘤中心,陕西西安710054

出　　处：《现代肿瘤医学》2013年第4期779-781,共3页Journal of Modern Oncology

基　　金：陕西省自然科学基金(编号:2012JM4008)

摘　　要：目的:探讨老年非小细胞肺癌低分割放疗的临床疗效。方法:收集接受胸部放疗的老年肺癌35例,单次分割剂量2.5Gy,总剂量50Gy。TNM分期Ⅱ、Ⅲ、Ⅳ期各6、18、11例。结果:随访6-24个月,随访率100%。放射性食管炎发生率22.9%、2级以上放射性肺炎发生率8.6%。近期疗效:CR 11.4%、PR 51.4%、SD 28.6%、PD 8.6%;1年生存率57.1%,2年生存率17.1%。结论:低分割放疗对老年肺癌患者近期疗效确切,放疗毒副反应可以耐受。Objective：To investigate the clinical efficacy of hypofractionated high- dose radiotherapy for elderly non - small - cell lung cancer. Methods： To analyze 53 cases of lung cancer received chest radiation therapy with dose fractionation 2.5GTc/d,5f/w, total dose 50Gy. TNM staging Ⅱ ,Ⅲ and IV were respectively ,6,18 and 11 cases. Results：Followed up for 6 -24 months, follow - up rate was 100%. Radiation esophagitis incidence was 22.9%. The radiation pneumonia rate was 8.6%. Short term efficacy： CR 11.4%, PR 51.4%, SD 28.6%, PD 8.6%. 1 - year survival rate was 57.1% ,2 - year survival rate was 17. 1%. Conclusion： Curative effect of non - small cell lung cancer patients treated by three - dimensional conformal hypofractionated high - dose radiotherapy is definitely, radiation side effects can be tolerated.

关 键 词：老年非小细胞肺癌 三维适形放射治疗 低分割 

分 类 号：R734.2[医药卫生—肿瘤]