miRNA在肝癌发生与转移中的研究进展  

Progression of the functions of microRNA on HCC on the carcinogenesis and metastasis

作　　者：张子兰[1] 贾筱琴[1] 

机构地区：[1]扬州大学医学院,江苏扬州225000

出　　处：《现代肿瘤医学》2013年第4期887-891,共5页Journal of Modern Oncology

基　　金：国家自然科学基金面上项目(编号:81273214);江苏省高校自然科学研究面上项目(编号:10KJB310017)

摘　　要：肝细胞癌(hepatocellular carcinoma,HCC)是我国常见的恶性肿瘤。转移、扩散是其预后不良的主要原因。因此,探索肿瘤发生、发展和侵袭转移的分子机制,寻求新的治疗靶点,对于提高肝癌的疗效具有重要意义。microRNA简称为miRNA,通常长度为19-25个核苷酸,广泛存在于真核生物中,是一类高度保守的非编码的小分子单链RNA。miRNA通过与靶mRNA3'-UTR区完全或部分互补结合,导致靶区降解或转录后翻译抑制,从而调控靶基因的表达。miRNA具有癌基因和抑癌基因的作用,直接或间接参与肝癌发生和发展。Hepatocellular carcinoma （HCC） is a common malignant tumor in our country. Metastasis and recurrence is the leading cause of mortality in HCC patients. Further study of miRNA will provide a novel therapeutic target of HCC. microRNAs （miRNAs） are small, noncoding single -stranded RNA of a class of highly conserved non -coding small molecules in eukaryotes. These miRNAs interact with the complementary sequences on target mRNAs through partially or complete complementarity at the post - transcriptional level, miRNAs are a group of tiny RNAs with a fundamental role in the regulation of gene expression, miRNA are oncogenes and tumor suppressor genes,some miRNAs directly or indirectly involve in the development and progression of HCC.

关 键 词：MICRORNA 肝癌 发生 转移 

分 类 号：R737.7[医药卫生—肿瘤]